Exploring free amino acid profiles in Crimean-Congo hemorrhagic fever patients: Implications for disease progression

Basit Öğe Kaydı
dc.authoridBagci, Gokhan/0000-0003-4554-2391
dc.authoridDOGAN, Kubra/0000-0002-9448-3407
dc.contributor.authorBuyuktuna, Seyit Ali
dc.contributor.authorYerlitas, Serra Ilayda
dc.contributor.authorZararsiz, Goezde Ertuk
dc.contributor.authorDogan, Kuebra
dc.contributor.authorKablan, Demet
dc.contributor.authorBagci, Gokhan
dc.contributor.authorOzer, Selda
dc.date.accessioned2025-02-06T17:58:25Z
dc.date.available2025-02-06T17:58:25Z
dc.date.issued2024
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractThis study investigated the intricate interplay between Crimean-Congo hemorrhagic fever virus infection and alterations in amino acid metabolism. The primary aim is to elucidate the impact of Crimean-Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography-tandem mass spectrometry techniques were employed to quantify amino acid concentrations. The amino acid metabolic profiles in CCHF patients exhibit substantial distinctions from those in the control group. Patients highlight distinct metabolic reprogramming, notably characterized by arginine, histidine, taurine, glutamic acid, and glutamine metabolism shifts. These changes have been associated with the underlying molecular mechanisms of the disease. Exploring novel therapeutic and diagnostic strategies addressing specific amino acids may offer potential means to mitigate the severity of the disease.en_US
dc.description.sponsorshipResearch Fund of Erciyes University; [TSG-2021-10912]en_US
dc.description.sponsorshipThis study was supported by the Research Fund of Erciyes University (TSG-2021-10912). The funders had no role in study design, data collection and analysis, publication decisions, or manuscript preparation.en_US
dc.identifier.doi10.1002/jmv.29637
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue5en_US
dc.identifier.pmid38773825
dc.identifier.scopus2-s2.0-85193825786
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.29637
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5242
dc.identifier.volume96en_US
dc.identifier.wosWOS:001232031300032
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250206
dc.subjectAmino aciden_US
dc.subjectCrimean-Congo hemorrhagic feveren_US
dc.subjectLC-MS/MSen_US
dc.subjectseverityen_US
dc.titleExploring free amino acid profiles in Crimean-Congo hemorrhagic fever patients: Implications for disease progressionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu