Endometrial injury concurrent with hysteroscopy increases the expression of Leukaemia inhibitory factor: A preliminary study

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dc.contributor.authorErşahin, Suat Süphan
dc.contributor.authorErşahin, Aynur
dc.date.accessioned2022-01-27T05:59:15Z
dc.date.available2022-01-27T05:59:15Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü,Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractIt is not known by which mechanism endometrial injury increases pregnancy rates. Leukaemia inhibitory factor (LIF) is a cytokine involved in wound healing and implantation. The aim of this study was to determine the change in endometrial LIF mRNA expression before and after mechanical injury during hysteroscopy. Methods: Forty patients with a history of two or more unsuccessful implantations who decided to undergo hysteroscopy in the proliferative phase were divided into two equal groups: one with endometrial injury (scratching group) and the other with noninjury (control group). Endometrial sampling was conducted before injury on the patients in the scratching group, and then injury was performed with monopolar needle forceps. Only diagnostic hysteroscopy was performed on the patients in the control group. Endometrial tissues were collected using a Pipelle catheter between Days 20 and 23 of the mid-luteal phase of the next cycles in both the scratching and control groups. Endometrial LIF mRNA expression was evaluated with the use of reverse-transcription polymerase chain reactions. Results: Relative changes in mRNA expression levels of the LIF gene in endometrial samples taken before and after injury were calculated using the 2-ΔΔCt method, and the fold changes obtained were compared between and within the groups. Compared with preinjury values, an 11.1-fold increase was found in postinjury LIF mRNA expression in patients with monopolar forceps injury (p < 0.001). There was a 3.9-fold signifcant increase in postinjury LIF mRNA levels compared with those in the control group (p < 0.02). Conclusions: The fertility-promoting efect of hysteroscopy-guided mechanical endometrial injury may be mediated by LIF mRNA.en_US
dc.identifier.citationErsahin, S. S., & Ersahin, A. (2022). Endometrial injury concurrent with hysteroscopy increases the expression of Leukaemia inhibitory factor: a preliminary study. Reproductive Biology and Endocrinology, 20(1), 1-6.en_US
dc.identifier.endpage6en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85122740949
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2227
dc.identifier.volume20en_US
dc.identifier.wosWOS:000740994100002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErşahin, Suat Süphan
dc.language.isoen
dc.publisherReproductive Biology and Endocrinologyen_US
dc.relation.ispartofReproductive Biology and Endocrinology
dc.relation.isversionof10.1186/s12958-021-00877-zen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometrial Injuryen_US
dc.subjectHysteroscopyen_US
dc.subjectMonopolar Forcepsen_US
dc.subjectLIF mRNAen_US
dc.subjectRT–PCRen_US
dc.titleEndometrial injury concurrent with hysteroscopy increases the expression of Leukaemia inhibitory factor: A preliminary study
dc.typeArticle

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