Comparison of Oxidative Stress Effects Between Drug-Eluting Stents and Drug-Coated Balloons: Insights Into Vascular Response and Clinical Implications
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Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Liss
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Percutaneous coronary intervention (PCI) has evolved with the development of drug-eluting stents (DES) and drug-coated balloons (DCB), both of which play a crucial role in reducing restenosis and major adverse cardiovascular events (MACE). Despite their benefits, the oxidative stress response triggered by these interventions and its implications for vascular healing remain unclear. Aims: This study aims to compare the oxidative stress burden associated with DES and DCB by evaluating changes in plasma total peroxidase (TP) levels over time. Methods: This observational, comparative study included 110 patients (60 DES and 50 DCB) who underwent PCI for stable coronary artery disease. TP levels were measured pre-procedure, 24 h postprocedure, and 1 month after PCI. Statistical comparisons were used to determine significant differences in oxidative stress between the two groups over time. Results: Preoperative TP levels were comparable between the DES and DCB groups (431.00 ± 4.56 vs. 436.50 ± 4.14 µmol/L, p = 0.110). At 24 h post-PCI, TP levels increased significantly in both groups (DES: 449.50 ± 6.51 µmol/L, DCB: 442.50 ± 4.14 µmol/L), with a greater rise observed in the DES group, though not statistically significant (p = 0.42). At the 1-month follow-up, TP levels decreased significantly below baseline in both groups, with a more pronounced reduction in the DCB group (398.50 ± 4.14 vs. 406.50 ± 4.51 µmol/L, p = 0.11). Conclusion: This study reveals that both DES and DCB procedures trigger an initial rise in oxidative stress markers, emphasizing their acute vascular impact. Intriguingly, although not statistically significant, the DCB group demonstrated a trend toward a more rapid decline in oxidative stress at 1 month post-PCI. These preliminary findings highlight the potential of DCBs to foster quicker vascular recovery, warranting further investigation into their long-term clinical advantages.
Açıklama
Anahtar Kelimeler
drug-coated balloons, drug-eluting stents, oxidative stress, percutaneous coronary intervention, total peroxidase
Kaynak
Catheterization and Cardiovascular Interventions
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
106
Sayı
4
Künye
Aslan, M., Okşen, D., Yavuz, Y. E., & Kaynak, Ç. (2025). Comparison of Oxidative Stress Effects Between Drug‐Eluting Stents and Drug‐Coated Balloons: Insights Into Vascular Response and Clinical Implications. Catheterization and Cardiovascular Interventions, 106(4), 2791-2798. 10.1002/ccd.70209
