Comparison of Oxidative Stress Effects Between Drug-Eluting Stents and Drug-Coated Balloons: Insights Into Vascular Response and Clinical Implications

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dc.contributor.authorAslan, Muzaffer
dc.contributor.authorOkşen, Doğaç
dc.contributor.authorYavuz, Yunus Emre
dc.contributor.authorKaynak, Çağdaş
dc.date.accessioned2025-10-17T11:56:55Z
dc.date.available2025-10-17T11:56:55Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground: Percutaneous coronary intervention (PCI) has evolved with the development of drug-eluting stents (DES) and drug-coated balloons (DCB), both of which play a crucial role in reducing restenosis and major adverse cardiovascular events (MACE). Despite their benefits, the oxidative stress response triggered by these interventions and its implications for vascular healing remain unclear. Aims: This study aims to compare the oxidative stress burden associated with DES and DCB by evaluating changes in plasma total peroxidase (TP) levels over time. Methods: This observational, comparative study included 110 patients (60 DES and 50 DCB) who underwent PCI for stable coronary artery disease. TP levels were measured pre-procedure, 24 h postprocedure, and 1 month after PCI. Statistical comparisons were used to determine significant differences in oxidative stress between the two groups over time. Results: Preoperative TP levels were comparable between the DES and DCB groups (431.00 ± 4.56 vs. 436.50 ± 4.14 µmol/L, p = 0.110). At 24 h post-PCI, TP levels increased significantly in both groups (DES: 449.50 ± 6.51 µmol/L, DCB: 442.50 ± 4.14 µmol/L), with a greater rise observed in the DES group, though not statistically significant (p = 0.42). At the 1-month follow-up, TP levels decreased significantly below baseline in both groups, with a more pronounced reduction in the DCB group (398.50 ± 4.14 vs. 406.50 ± 4.51 µmol/L, p = 0.11). Conclusion: This study reveals that both DES and DCB procedures trigger an initial rise in oxidative stress markers, emphasizing their acute vascular impact. Intriguingly, although not statistically significant, the DCB group demonstrated a trend toward a more rapid decline in oxidative stress at 1 month post-PCI. These preliminary findings highlight the potential of DCBs to foster quicker vascular recovery, warranting further investigation into their long-term clinical advantages.
dc.identifier.citationAslan, M., Okşen, D., Yavuz, Y. E., & Kaynak, Ç. (2025). Comparison of Oxidative Stress Effects Between Drug‐Eluting Stents and Drug‐Coated Balloons: Insights Into Vascular Response and Clinical Implications. Catheterization and Cardiovascular Interventions, 106(4), 2791-2798. 10.1002/ccd.70209
dc.identifier.doi10.1002/ccd.70209
dc.identifier.endpage2798
dc.identifier.issn1522-1946
dc.identifier.issn1522-726X
dc.identifier.issue4
dc.identifier.pmid40988378
dc.identifier.scopus2-s2.0-105017784537
dc.identifier.scopusqualityQ2
dc.identifier.startpage2791
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5967
dc.identifier.volume106
dc.identifier.wosWOS:001577001100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorOkşen, Doğaç
dc.language.isoen
dc.publisherWiley-Liss
dc.relation.ispartofCatheterization and Cardiovascular Interventions
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdrug-coated balloons
dc.subjectdrug-eluting stents
dc.subjectoxidative stress
dc.subjectpercutaneous coronary intervention
dc.subjecttotal peroxidase
dc.titleComparison of Oxidative Stress Effects Between Drug-Eluting Stents and Drug-Coated Balloons: Insights Into Vascular Response and Clinical Implications
dc.typeOther

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