Visualisation of real-time oral biodistribution of fluorescent labeled self-microemulsifying drug delivery system of olmesartan medoxomil using optical imaging method
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Japanese Soc Study Xenobiotics
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the present study, the biodistribution of self-microemulsifying drug delivery system of hydrophobic olmesartan medoxomil (OM-SMEDDS) was determined by labeling with a fluorescent dye VivoTag (R) 680 XL and Xenolight (R) DiR. Labeled OM-SMEDDS and control dye solution administered orally to mice; real-time dynamic biodistributions over 7 h were determined by 2D-fluorescent imaging to verify their anatomic location. Fluorescent Emissions by Vivotag 680 (R) XL and Xenolight (R) DiR labeled OM-SMEDDS emitted 2 to 24 times stronger emission than control dye administered group. To further confirm the results, organs were removed and examined using the same technique at the end of 7 h. VivoTag (R) 680XL and Xenolight (R) DiR emitted 4 and 1.7 times stronger emission respectively than control dye administered mice in ex-vivo organ imaging studies. This study showed that OM-SMEDDS can be succesfully labeled with fluorescent dye and tracked with optical imaging method for the visualisation of biodistribution of drugs and is also useful for enhanced bioavailability. (C) 2020 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.
Açıklama
YILDIRIM, Yeliz/0000-0002-3014-4510; Komesli, Yelda/0000-0001-8086-6506
Anahtar Kelimeler
Biodistribution, SMEDDS, Pharmacokinetics, Real-time Fluorescent Imaging, Near Infrared (NIR), Olmesartan, Vivotag, Xenolight, Optical Imaging
Kaynak
Drug Metabolism and Pharmacokinetics
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
36
