Visualisation of real-time oral biodistribution of fluorescent labeled self-microemulsifying drug delivery system of olmesartan medoxomil using optical imaging method

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dc.contributor.authorKömesli, Yelda
dc.contributor.authorYıldırım, Yeliz
dc.contributor.authorKarasulu, Ercument
dc.date.accessioned2021-05-15T11:33:16Z
dc.date.available2021-05-15T11:33:16Z
dc.date.issued2021
dc.departmentEczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalıen_US
dc.descriptionYILDIRIM, Yeliz/0000-0002-3014-4510; Komesli, Yelda/0000-0001-8086-6506
dc.description.abstractIn the present study, the biodistribution of self-microemulsifying drug delivery system of hydrophobic olmesartan medoxomil (OM-SMEDDS) was determined by labeling with a fluorescent dye VivoTag (R) 680 XL and Xenolight (R) DiR. Labeled OM-SMEDDS and control dye solution administered orally to mice; real-time dynamic biodistributions over 7 h were determined by 2D-fluorescent imaging to verify their anatomic location. Fluorescent Emissions by Vivotag 680 (R) XL and Xenolight (R) DiR labeled OM-SMEDDS emitted 2 to 24 times stronger emission than control dye administered group. To further confirm the results, organs were removed and examined using the same technique at the end of 7 h. VivoTag (R) 680XL and Xenolight (R) DiR emitted 4 and 1.7 times stronger emission respectively than control dye administered mice in ex-vivo organ imaging studies. This study showed that OM-SMEDDS can be succesfully labeled with fluorescent dye and tracked with optical imaging method for the visualisation of biodistribution of drugs and is also useful for enhanced bioavailability. (C) 2020 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipAliye Uster Foundation [15ECZ-014]en_US
dc.description.sponsorshipThe authors express deep gratitude to the Aliye Uster Foundation for their generous funding of this research (Grant Number 15ECZ-014).en_US
dc.identifier.doi10.1016/j.dmpk.2020.10.004
dc.identifier.issn1347-4367
dc.identifier.issn1880-0920
dc.identifier.pmid33191089
dc.identifier.scopus2-s2.0-85096161978
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.dmpk.2020.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.12939/115
dc.identifier.volume36en_US
dc.identifier.wosWOS:000612227200004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKömesli, Yelda
dc.language.isoen
dc.publisherJapanese Soc Study Xenobioticsen_US
dc.relation.ispartofDrug Metabolism and Pharmacokinetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiodistributionen_US
dc.subjectSMEDDSen_US
dc.subjectPharmacokineticsen_US
dc.subjectReal-time Fluorescent Imagingen_US
dc.subjectNear Infrared (NIR)en_US
dc.subjectOlmesartanen_US
dc.subjectVivotagen_US
dc.subjectXenolighten_US
dc.subjectOptical Imagingen_US
dc.titleVisualisation of real-time oral biodistribution of fluorescent labeled self-microemulsifying drug delivery system of olmesartan medoxomil using optical imaging method
dc.typeArticle

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