Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens

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dc.contributor.authorKavruk, Murat
dc.contributor.authorÇelikbıçak, Ömer
dc.contributor.authorÖzalp, Veli Cengiz
dc.contributor.authorBorsa, Barış Ata
dc.contributor.authorHernandez, Frank J.
dc.contributor.authorBayramoğlu, Gülay
dc.contributor.authorArıca, Yakup
dc.date.accessioned2021-05-15T12:40:37Z
dc.date.available2021-05-15T12:40:37Z
dc.date.issued2015
dc.departmentTıp Fakültesien_US
dc.descriptionOzalp, Veli Cengiz/0000-0002-7659-5990; Kavruk, Murat/0000-0001-5331-7253; Hernandez, Frank J./0000-0001-6308-8087; Celikbicak, Omur/0000-0003-2683-0312
dc.description.abstractIn this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.en_US
dc.description.sponsorshipTUBITAK 1001 grantTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [213M315]en_US
dc.description.sponsorshipThis work was supported by TUBITAK 1001 grant no: 213M315.en_US
dc.identifier.doi10.1039/c5cc01869b
dc.identifier.endpage8495en_US
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X
dc.identifier.issue40en_US
dc.identifier.pmid25891472
dc.identifier.scopus2-s2.0-84928975142
dc.identifier.scopusqualityQ1
dc.identifier.startpage8492en_US
dc.identifier.urihttps://doi.org/10.1039/c5cc01869b
dc.identifier.urihttps://hdl.handle.net/20.500.12939/633
dc.identifier.volume51en_US
dc.identifier.wosWOS:000354043200024
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBorsa, Barış Ata
dc.language.isoen
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofChemical Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPathogensen_US
dc.titleAntibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens
dc.typeArticle

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