"Metformin-resistant" folic acid producing probiotics or folic acid against metformin's adverse effects like diarrhea
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Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Churchill Livingstone
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Metformin, first line medication in the treatment of type2 diabetes by millions of patients worldwide, causes gastrointestinal adverse effects (i.e. diarrhea) in approximately 30% of patients, frequently leading to discontinuation. Interestingly, metformin was reported to increase life span in a microscopic worm, Caenorhabditis elegans, by decreasing folate and methionine production of bacteria that this worm uses as a food source. Metformin can be expected to have a similar effect on some microorganisms of human gut microbiota. This can disturb the balance of gut microbiota and cause gastrointestinal adverse effects by altering folate production of some types of bacteria and suppress their growth. Metformin resistant probiotics can be discovered or generated by artificial evolution/selection, and used to prevent these adverse effects. These patients can also be managed with folate supplementation. (C) 2017 Elsevier Ltd. All rights reserved.
Açıklama
Olgun, Abdullah/0000-0002-6976-9286
Anahtar Kelimeler
Medicine, Probiotics, Diarrhea, Metformin-Resistant
Kaynak
Medical Hypotheses
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
106
