"Metformin-resistant" folic acid producing probiotics or folic acid against metformin's adverse effects like diarrhea

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dc.contributor.authorOlgun, Abdullah
dc.date.accessioned2021-05-15T12:42:58Z
dc.date.available2021-05-15T12:42:58Z
dc.date.issued2017
dc.departmentEczacılık Fakültesien_US
dc.descriptionOlgun, Abdullah/0000-0002-6976-9286
dc.description.abstractMetformin, first line medication in the treatment of type2 diabetes by millions of patients worldwide, causes gastrointestinal adverse effects (i.e. diarrhea) in approximately 30% of patients, frequently leading to discontinuation. Interestingly, metformin was reported to increase life span in a microscopic worm, Caenorhabditis elegans, by decreasing folate and methionine production of bacteria that this worm uses as a food source. Metformin can be expected to have a similar effect on some microorganisms of human gut microbiota. This can disturb the balance of gut microbiota and cause gastrointestinal adverse effects by altering folate production of some types of bacteria and suppress their growth. Metformin resistant probiotics can be discovered or generated by artificial evolution/selection, and used to prevent these adverse effects. These patients can also be managed with folate supplementation. (C) 2017 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.mehy.2017.07.009
dc.identifier.endpage34en_US
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.pmid28818268
dc.identifier.scopus2-s2.0-85022342705
dc.identifier.scopusqualityQ1
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2017.07.009
dc.identifier.urihttps://hdl.handle.net/20.500.12939/993
dc.identifier.volume106en_US
dc.identifier.wosWOS:000409290600008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOlgun, Abdullah
dc.language.isoen
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofMedical Hypotheses
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMedicineen_US
dc.subjectProbioticsen_US
dc.subjectDiarrheaen_US
dc.subjectMetformin-Resistanten_US
dc.title"Metformin-resistant" folic acid producing probiotics or folic acid against metformin's adverse effects like diarrhea
dc.typeArticle

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