Cytotoxic efects of diferent detergent containing children’s toothpastes on human gingival epithelial cells

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dc.contributor.authorBirant, Sinem
dc.contributor.authorDuran, Yazgül
dc.contributor.authorAkkoç, Tunç
dc.date.accessioned2022-03-30T06:33:19Z
dc.date.available2022-03-30T06:33:19Z
dc.date.issued2022en_US
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalıen_US
dc.description.abstractBackground: This study aimed to evaluate possible cytotoxic efects to gingival epithelial cells exposed to children toothpastes containing diferent detergent. Methods: Tissues required for the isolation of human gingival epithelial cells were obtained by biopsy during the extraction of the impacted third molar tooth. Toothpaste solutions of diferent concentrations were prepared from fve diferent children’s toothpastes with diferent detergent contents. Isolated gingival epithelial cells were stimulated with experimental groups consisting of toothpaste solutions (Colgate, Sensodyne, Splat, Nenedent, Perlodent) at diferent concentrations and a control group consisting of complete Dulbecco’s modifed eagle medium. After the experiments, cell viability was evaluated using fow cytometry. 2 Way ANOVA was used to see the interaction efect of the main efects of toothpaste solution and concentration factors. Pairwise comparisons were made by Tukey post hoc tests. In the study, the signifcance level was taken as 0.05. Results: As a result of the analysis, it was seen that the toothpaste solution and concentration factors and the interactions of these 2 factors were efective on the viable, early apoptotic, late apoptotic and necrotic cell rates. The statistically highest live cell ratios were detected in Splat’s toothpaste solutions (90.14% at 0.4% concentration) after the control group (90.82%) and the group with the lowest viability values was determined in Colgate group (75.74% at 0.4% concentration)en_US
dc.identifier.citationBirant, S., Duran, Y., Akkoc, T., & Seymen, F. (2022). Cytotoxic effects of different detergent containing children's toothpastes on human gingival epithelial cells. BMC Oral Health, 22(1), 1-16.en_US
dc.identifier.endpage16en_US
dc.identifier.issn14726831
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85126077293
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2304
dc.identifier.volume22en_US
dc.identifier.wosWOS:000766564200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSeymen, Figen
dc.language.isoen
dc.publisherBMC Oral Healthen_US
dc.relation.ispartofBMC Oral Health
dc.relation.isversionof10.1186/s12903-022-02089-2en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectToothpasteen_US
dc.subjectStem Cellen_US
dc.subjectAnnexin Ven_US
dc.subjectDetergenten_US
dc.subjectSLSen_US
dc.titleCytotoxic efects of diferent detergent containing children’s toothpastes on human gingival epithelial cells
dc.typeArticle

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