Effects of thymoquinone (TQ) on the molecular structure and total antioxidant capacity of cerebellum tissue of healthy rats
Yükleniyor...
Dosyalar
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The neuroprotective effects of thymoquinone (TQ), the active compound of Nigella sativa, have been reported in accordance
with the anti-inflammatory and antioxidant features of this drug. It has been suggested that the cerebellum plays a considerable role in
neurodegenerative processes. In the current study, the possible effects of TQ on the structure and composition of cerebellum tissues and
its total antioxidant capacity were studied dose-dependently.
Materials and Methods: Fifteen adult Long Evans female rats were divided into groups as follows: G1: Control, G2: 10 mg/kg TQ treatment,
G3: 20 mg/kg TQ treatment. TQ was injected into the rats intraperitoneally for two weeks. The control group only received corn oil used
for the dissolving of TQ. Fourier-transform infrared spectroscopy (FTIR) studies and total protein, and antioxidant capacity measurements
were carried out with cerebellum tissues which were removed following the decapitation of rats.
Results and Conclusion: 10 mg/kg TQ treatment improved the saturated and unsaturated lipid and protein content in addition to
decreasing nucleic acid content and lipid peroxidation and increasing the total antioxidant capacity of cerebellum tissues. However, 20
mg/kg TQ treatment did not have any significant effect.
Açıklama
Anahtar Kelimeler
Thymoquinone, Cerebellum, Total Antioxidant Capacity, FTIR Spectroscopy
Kaynak
Experimed
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
12
Sayı
2
Künye
Garip Ustaoğlu, Ş., Elibol, B. (2022). Effects of thymoquinone (TQ) on the molecular structure and total antioxidant capacity of cerebellum tissue of healthy rats. Experimed, 12(2), 94-102.
