Effects of thymoquinone (TQ) on the molecular structure and total antioxidant capacity of cerebellum tissue of healthy rats

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dc.authorid0000-0001-6577-9578en_US
dc.contributor.authorGarip Ustaoğlu, Şebnem
dc.contributor.authorElibol, Birsen
dc.date.accessioned2023-02-27T08:17:46Z
dc.date.available2023-02-27T08:17:46Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractObjective: The neuroprotective effects of thymoquinone (TQ), the active compound of Nigella sativa, have been reported in accordance with the anti-inflammatory and antioxidant features of this drug. It has been suggested that the cerebellum plays a considerable role in neurodegenerative processes. In the current study, the possible effects of TQ on the structure and composition of cerebellum tissues and its total antioxidant capacity were studied dose-dependently. Materials and Methods: Fifteen adult Long Evans female rats were divided into groups as follows: G1: Control, G2: 10 mg/kg TQ treatment, G3: 20 mg/kg TQ treatment. TQ was injected into the rats intraperitoneally for two weeks. The control group only received corn oil used for the dissolving of TQ. Fourier-transform infrared spectroscopy (FTIR) studies and total protein, and antioxidant capacity measurements were carried out with cerebellum tissues which were removed following the decapitation of rats. Results and Conclusion: 10 mg/kg TQ treatment improved the saturated and unsaturated lipid and protein content in addition to decreasing nucleic acid content and lipid peroxidation and increasing the total antioxidant capacity of cerebellum tissues. However, 20 mg/kg TQ treatment did not have any significant effect.en_US
dc.identifier.citationGarip Ustaoğlu, Ş., Elibol, B. (2022). Effects of thymoquinone (TQ) on the molecular structure and total antioxidant capacity of cerebellum tissue of healthy rats. Experimed, 12(2), 94-102.en_US
dc.identifier.endpage102en_US
dc.identifier.issn2630-6050
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage94en_US
dc.identifier.trdizinid1125269
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3417
dc.identifier.volume12en_US
dc.identifier.wosWOS:001325929200010
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorGarip Ustaoğlu, Şebnem
dc.language.isoen
dc.relation.ispartofExperimed
dc.relation.isversionof10.26650/experimed.1128979en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectCerebellumen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectFTIR Spectroscopyen_US
dc.titleEffects of thymoquinone (TQ) on the molecular structure and total antioxidant capacity of cerebellum tissue of healthy rats
dc.typeArticle

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