Enterotoksijenik bacteroides fragilis ve fusobacterium nucleatum bağırsak kolonizasyonunun kolorektal kanser ile ilişkisi: kolon biyopsileri ile yapılan bir olgu kontrol çalışması

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dc.authorid0000-0003-0336-1832en_US
dc.contributor.authorÖztürk Bakar, Yeşim
dc.contributor.authorDemiryas, Süleyman
dc.contributor.authorKılınçarslan, Ayşe Ceylan
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorKepil, Nuray
dc.contributor.authorBakar, Murat Tuğberk
dc.contributor.authorTaner, Zeynep
dc.contributor.authorTokuç, Edip
dc.contributor.authorZiyad, Muhuyedin Abdırahman
dc.contributor.authorTaşkı, İhsan
dc.contributor.authorKocazeybek, Bekir Sami
dc.contributor.authorTokman, Hrisi Bahar
dc.date.accessioned2023-07-25T07:32:24Z
dc.date.available2023-07-25T07:32:24Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractIn recent years, it has been shown that some bacteria may be associated with colorectal cancer (CRC). In this study, it was aimed to investigate the role of Fusobacterium nucleatum and enterotoxigenic Bacteroides fragilis (ETBF) in the etiology of CRC by comparing the amounts of these bacteria in colon biopsy tissues of patients with CRC and healthy individuals. The amounts of F.nucleatum and ETBF were determined by quantitative polymerase chain reaction (qPCR) in colon biopsy samples taken from 35 CRC and 35 healthy individuals, and the results were compared in the patient and control groups. The detection rate and amounts of F.nucleatum were found to be statistically significantly higher in tissues of female patients with CRC compared to male patients (p= 0.003, p= 0.013, respectively). There was no statistically significant difference between the tissues of female and male patients with CRC in terms of detection rate and amount of ETBF (p= 0.521, p= 0.515, respectively). It was found that in the 50-74 age group, the amount of ETBF was statistically significantly higher in women and men with CRC compared to the controls (p= 0.005, p= 0.047, respectively), while the amount of F.nucleatum was statistically significantly higher in female patients compared to controls. However, no difference was found between male patients and controls (p= 0.009, p= 0.083). It was determined that the detection rate and amount of F.nucleatum in the tissues of patients with CRC, regardless of age and gender, were not statistically different from the controls (p= 0.473, p= 0.995, respectively), however, the detection rate of ETBF and the amount of ETBF were found to be statistically significantly higher (p= 0.002, p= 0.004, respectively). It has been determined that ETBF can play a role in the etiology of CRC in both men and women, and F.nucleatum only in women, in the age range of 50-74 years, when routine screenings for CRC are performed.en_US
dc.identifier.citationDemiryas, S., Demirci, M., Kepil, N., Bakar, M. T., Taner, Z., Tokuç, E., ... & Tokman, B. (2023). [The relationship of enterotoxigenic bacteroides fragilis and fusobacterium nucleatum intestinal colonization with colorectal cancer: a case-control study performed with colon biopsies]. Mikrobiyoloji Bulteni, 57(3), 353-364.en_US
dc.identifier.endpage364en_US
dc.identifier.issn0374-9096
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85165103211
dc.identifier.scopusqualityQ3
dc.identifier.startpage353en_US
dc.identifier.trdizinid1194520
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3608
dc.identifier.volume57en_US
dc.identifier.wosWOS:001070931100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorTaner, Zeynep
dc.language.isotr
dc.relation.ispartofMikrobiyoloji bu¨lteni
dc.relation.isversionof10.5578/mb.20239929en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKolorektal kanseren_US
dc.subjectFusobacterium nucleatumen_US
dc.subjectEnterotoksijenik Bacteroides fragilisen_US
dc.subjectqPCRen_US
dc.titleEnterotoksijenik bacteroides fragilis ve fusobacterium nucleatum bağırsak kolonizasyonunun kolorektal kanser ile ilişkisi: kolon biyopsileri ile yapılan bir olgu kontrol çalışması
dc.title.alternative[The relationship of enterotoxigenic bacteroides fragilis and fusobacterium nucleatum intestinal colonization with colorectal cancer: a case-control study performed with colon biopsies]
dc.typeArticle

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