An in vitro assessment of teething gels' effects on human gingival mesenchymal stem cells
Yükleniyor...
Dosyalar
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The aim of this study is to examine the cytotoxic effects of dental gels with different contents, which are frequently used during teething, on gingival mesenchymal stem cells (G-MSCs).
Method: The teething gels used in this study were Dentinox, Gengigel, Osanite, and Jack and Jill. The human gingival mesenchimal stem cells (hG-MSCs) were incubated with these teething gel solutions (0.1%, 50% and 80% concentrations). Reproductive behavior of G-MSCs was monitored in real time for 72 h using the xCELLigence real-time cell analyzer (RTCA) system. Two-way repeated Anova test and post hoc Bonferroni test were used to evaluate the effect of concentration and dental gel on 0-hour and 72-hour viability. Significance was evaluated at p < 0.05 level.
Results: Teething gels prepared at 50% concentration are added to the G-MSC culture, the "cell index" value of G-MSCs to which Dentinox brand gel is added is significantly lower than all other groups (p = 0.05). There is a statistically significant difference between the concentrations in terms of cell index values at the 72nd hour compared to the 0th hour (p = 0.001).
Conclusions: The local anesthetic dental gels used in children have a more negative effect on cell viability as concentration increases.
Açıklama
Anahtar Kelimeler
Cell viability, Hyaluranic acid, Lidocain, Stem cell, Teething gel
Kaynak
BMC Oral Health
WoS Q Değeri
Q1
Scopus Q Değeri
Q2
Cilt
24
Sayı
1
Künye
Birant, S., İlisulu, S. C., Kılıç, S., Tunca, Z., Özcan, H., Akkoç, T., Seymen, F. (2024). An in vitro assessment of teething gels' effects on human gingival mesenchymal stem cells. BMC Oral Health, 24(1). 10.1186/s12903-024-04213-w
