An in vitro assessment of teething gels' effects on human gingival mesenchymal stem cells

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dc.contributor.authorBirant, Sinem
dc.contributor.authorİlisulu, Sabiha Ceren
dc.contributor.authorKılıç, Senem
dc.contributor.authorTunca, Zeynep
dc.contributor.authorÖzcan, Hazal
dc.contributor.authorAkkoç, Tunç
dc.contributor.authorSeymen, Figen
dc.date.accessioned2024-05-22T07:31:17Z
dc.date.available2024-05-22T07:31:17Z
dc.date.issued2024en_US
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalıen_US
dc.description.abstractBackground: The aim of this study is to examine the cytotoxic effects of dental gels with different contents, which are frequently used during teething, on gingival mesenchymal stem cells (G-MSCs). Method: The teething gels used in this study were Dentinox, Gengigel, Osanite, and Jack and Jill. The human gingival mesenchimal stem cells (hG-MSCs) were incubated with these teething gel solutions (0.1%, 50% and 80% concentrations). Reproductive behavior of G-MSCs was monitored in real time for 72 h using the xCELLigence real-time cell analyzer (RTCA) system. Two-way repeated Anova test and post hoc Bonferroni test were used to evaluate the effect of concentration and dental gel on 0-hour and 72-hour viability. Significance was evaluated at p < 0.05 level. Results: Teething gels prepared at 50% concentration are added to the G-MSC culture, the "cell index" value of G-MSCs to which Dentinox brand gel is added is significantly lower than all other groups (p = 0.05). There is a statistically significant difference between the concentrations in terms of cell index values at the 72nd hour compared to the 0th hour (p = 0.001). Conclusions: The local anesthetic dental gels used in children have a more negative effect on cell viability as concentration increases.en_US
dc.identifier.citationBirant, S., İlisulu, S. C., Kılıç, S., Tunca, Z., Özcan, H., Akkoç, T., Seymen, F. (2024). An in vitro assessment of teething gels' effects on human gingival mesenchymal stem cells. BMC Oral Health, 24(1). 10.1186/s12903-024-04213-wen_US
dc.identifier.issn1472-6831
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85193464677
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4699
dc.identifier.volume24en_US
dc.identifier.wosWOS:001227194100003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİlisulu, Sabiha Ceren
dc.institutionauthorÖzcan, Hazal
dc.institutionauthorSeymen, Figen
dc.language.isoen
dc.relation.ispartofBMC Oral Health
dc.relation.isversionof10.1186/s12903-024-04213-wen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCell viabilityen_US
dc.subjectHyaluranic aciden_US
dc.subjectLidocainen_US
dc.subjectStem cellen_US
dc.subjectTeething gelen_US
dc.titleAn in vitro assessment of teething gels' effects on human gingival mesenchymal stem cells
dc.typeArticle

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