Innovative fluorescent polymers in niosomal carriers: a novel approach to enhancing cancer therapy and imaging
Yükleniyor...
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Cancer is anticipated to become the pioneer reason of disease-related deaths worldwide in the next two decades, underscoring the urgent need for personalized and adaptive treatment strategies. These strategies are crucial due to the high variability in drug efficacy and the tendency of cancer cells to develop resistance. This study investigates the potential of theranostic nanotechnology using three innovative fluorescent polymers (FP-1, FP-2, and FP-3) encapsulated in niosomal carriers, combining therapy (chemotherapy and radiotherapy) with fluorescence imaging. These cargoes are assessed for their cytotoxic effects across three cancer cell lines (A549, MCF-7, and HOb), with further analysis to determine their capacity to augment the effects of radiotherapy using a Linear Accelerator (LINAC) at specific doses. Fluorescence microscopy is utilized to verify their uptake and localization in cancerous versus healthy cell lines. The results confirmed that these niosomal cargoes not only improved the antiproliferative effects of radiotherapy but also demonstrate the practical application of fluorescent polymers in in vitro imaging. This dual function underscores the importance of dose optimization to maximize therapeutic benefits while minimizing adverse effects, thereby enhancing the overall efficacy of cancer treatments.
Açıklama
Anahtar Kelimeler
Fluorescent polymers, Niosomes, Radiotherapy, Theranostic treatment
Kaynak
Macromolecular Bioscience
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
24
Sayı
10
Künye
tornacı, S., Erginer, M., Bulut, U., Şener, B., Persilioğlu, E., Kalaycılar, İ. B., Güler Çelik, E., Yardibi, H., Siyah, P., Karakurt, O., Çırpan, A., Gökalsın, B., Şenışık, A. M., Barlas, F. B. (2024). Innovative fluorescent polymers in niosomal carriers: a novel approach to enhancing cancer therapy and imaging. Macromolecular Bioscience, 24(10). 10.1002/mabi.202400343
