Innovative fluorescent polymers in niosomal carriers: a novel approach to enhancing cancer therapy and imaging

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dc.contributor.authorTornacı, Selay
dc.contributor.authorErginer, Merve
dc.contributor.authorBulut, Umut
dc.contributor.authorŞener, Beste
dc.contributor.authorPersilioğlu, Elifsu
dc.contributor.authorKalaycılar, İsmail Bergutay
dc.contributor.authorÇelik, Emine Güler
dc.contributor.authorYardibi, Hasret
dc.contributor.authorSiyah, Pınar
dc.contributor.authorKarakurt, Oğuzhan
dc.contributor.authorÇırpan, Ali
dc.contributor.authorGökalsın, Barış
dc.contributor.authorŞenışık, Ahmet Murat
dc.contributor.authorBarlas, Fırat Barış
dc.date.accessioned2024-09-11T05:39:07Z
dc.date.available2024-09-11T05:39:07Z
dc.date.issued2024en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Radyoterapi Programıen_US
dc.description.abstractCancer is anticipated to become the pioneer reason of disease-related deaths worldwide in the next two decades, underscoring the urgent need for personalized and adaptive treatment strategies. These strategies are crucial due to the high variability in drug efficacy and the tendency of cancer cells to develop resistance. This study investigates the potential of theranostic nanotechnology using three innovative fluorescent polymers (FP-1, FP-2, and FP-3) encapsulated in niosomal carriers, combining therapy (chemotherapy and radiotherapy) with fluorescence imaging. These cargoes are assessed for their cytotoxic effects across three cancer cell lines (A549, MCF-7, and HOb), with further analysis to determine their capacity to augment the effects of radiotherapy using a Linear Accelerator (LINAC) at specific doses. Fluorescence microscopy is utilized to verify their uptake and localization in cancerous versus healthy cell lines. The results confirmed that these niosomal cargoes not only improved the antiproliferative effects of radiotherapy but also demonstrate the practical application of fluorescent polymers in in vitro imaging. This dual function underscores the importance of dose optimization to maximize therapeutic benefits while minimizing adverse effects, thereby enhancing the overall efficacy of cancer treatments.en_US
dc.identifier.citationtornacı, S., Erginer, M., Bulut, U., Şener, B., Persilioğlu, E., Kalaycılar, İ. B., Güler Çelik, E., Yardibi, H., Siyah, P., Karakurt, O., Çırpan, A., Gökalsın, B., Şenışık, A. M., Barlas, F. B. (2024). Innovative fluorescent polymers in niosomal carriers: a novel approach to enhancing cancer therapy and imaging. Macromolecular Bioscience, 24(10). 10.1002/mabi.202400343en_US
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85202844100
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4897
dc.identifier.volume24en_US
dc.identifier.wosWOS:001302014400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofMacromolecular Bioscience
dc.relation.isversionof10.1002/mabi.202400343en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFluorescent polymersen_US
dc.subjectNiosomesen_US
dc.subjectRadiotherapyen_US
dc.subjectTheranostic treatmenten_US
dc.titleInnovative fluorescent polymers in niosomal carriers: a novel approach to enhancing cancer therapy and imaging
dc.typeArticle

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