Effects of calcium silicate-based cements on odonto/ osteogenic differentiation potential in mesenchymal stem cells

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dc.contributor.authorErcal, Pınar
dc.contributor.authorŞişmanoğlu, Soner
dc.date.accessioned2022-03-17T07:29:35Z
dc.date.available2022-03-17T07:29:35Z
dc.date.issued2022en_US
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Restoratif Diş Tedavisi Ana Bilim Dalıen_US
dc.description.abstractThe objective of this study was to evaluate the biological effects and odonto/osteogenic differentiation potential of Biodentine, NeoMTA Plus and TheraCal LC in tooth germ-derived stem cells(TGSCs). TGSCs were exposed to the material extracts. Biocompatibility was tested with MTS cell proliferation assay. Odonto/osteogenic differentiation was assessed with alkaline phosphatase (ALP) activity and mRNA gene expressions (RUNX2, DSPP and DMP-1). Scanning electronic microscopy/ energy-dispersive X-ray (SEM/EDX) analysis and pH analysis were also performed for the materials. Data were evaluated using the one-way ANOVA and Tukey's tests. TGSCs remained viable after 7 days of incubation with all tested materials. Biodentine and NeoMTA Plus showed high ALP activity and increased expression of RUNX2, DSPP and DMP-1 compared to that of TheraCal LC. All materials can induce odonto/osteogenic differentiation of MSCs in various levels. Biocompatibility and odonto/osteogenic differentiation potential of Biodentine and NeoMTA Plus are similar and superior to that of TheraCal LC.en_US
dc.identifier.citationSismanoglu, S., & Ercal, P. (2022). Effects of calcium silicate‐based cements on odonto/osteogenic differentiation potential in mesenchymal stem cells. Australian Endodontic Journal.en_US
dc.identifier.endpage74en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85125411303
dc.identifier.scopusqualityQ2
dc.identifier.startpage66en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2284
dc.identifier.volume49en_US
dc.identifier.wosWOS:000783032300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞişmanoğlu, Soner
dc.language.isoen
dc.publisherAustralian Endodontic Journalen_US
dc.relation.ispartofAustralian Endodontic Journal
dc.relation.isversionof10.1111/aej.12615en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalcium Silicatesen_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subjectMesenchymal Stem Cellsen_US
dc.subjectOdonto/Osteogenic Differentiationen_US
dc.subjectPulp Cappingen_US
dc.subjectVital Pulp Therapyen_US
dc.titleEffects of calcium silicate-based cements on odonto/ osteogenic differentiation potential in mesenchymal stem cells
dc.typeArticle

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