Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review
Yükleniyor...
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Patients with chronic kidney disease (CKD) often experience mild cognitive impairment and other neurocognitive disorders. Studies have shown that erythropoietin (EPO) and its receptor have neuroprotective effects in cell and animal models of nervous system disorders. Recombinant human EPO (rHuEPO), commonly used to treat anemia in CKD patients, could be a neuroprotective agent. In this systematic review, we aimed to assess the published studies investigating the cognitive benefits of rHuEPO treatment in individuals with reduced kidney function. We comprehensively searched Pubmed, Cochrane Library, Scopus, and Web of Science databases from 1990 to 2023. After selection, 24 studies were analyzed, considering study design, sample size, participant characteristics, intervention, and main findings. The collective results of these studies in CKD patients indicated that rHuEPO enhances brain function, improves performance on neuropsychological tests, and positively affects electroencephalography measurements. These findings suggest that rHuEPO could be a promising neuroprotective agent for managing CKD-related cognitive impairment.
Açıklama
Anahtar Kelimeler
CKD, Cognition, Darbepoetin, Erythropoietin, Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors (PHIs), Neuroprotection, Systematic review, rHuEPO
Kaynak
Pharmacological Research
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
203
Sayı
Künye
Barbieri, M., Chiodini, P., Di Gennaro, p., Hafez, G., Liabeuf, S., Malyszko, J., Mani, L.-Y., Raso, F. M., Pepin, M., Perico, N., Simeoni, M., Zoccali, C., Tortorella, G., Capuano, A., Remuzzi, G., Capasso, G., Paolisso, G., CONNECT Action collaborators. (2024). Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review. Pharmacological Research, 203. 10.1016/j.phrs.2024.107146
