Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review

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dc.contributor.authorBarbieri, Michelangela
dc.contributor.authorChiodini, Paolo
dc.contributor.authorDi Gennaro, Piergiacomo
dc.contributor.authorHafez, Gaye
dc.contributor.authorLiabeuf, Sophie
dc.contributor.authorMalyszko, Jolanta
dc.contributor.authorMani, Laila-Yasmin
dc.contributor.authorRaso, Francesco Mattace
dc.contributor.authorPepin, Marion
dc.contributor.authorPerico, Norberto
dc.contributor.authorSimeoni, Mariadelina
dc.contributor.authorZoccali, Carmine
dc.contributor.authorTortorella, Giovanni
dc.contributor.authorCapuano, Annalisa
dc.contributor.authorRemuzzi, Giuseppe
dc.contributor.authorCapasso, Giovambattista
dc.contributor.authorPaolisso, Giuseppe
dc.contributor.authorCONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target) collaborators
dc.date.accessioned2024-03-30T11:50:49Z
dc.date.available2024-03-30T11:50:49Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalıen_US
dc.description.abstractPatients with chronic kidney disease (CKD) often experience mild cognitive impairment and other neurocognitive disorders. Studies have shown that erythropoietin (EPO) and its receptor have neuroprotective effects in cell and animal models of nervous system disorders. Recombinant human EPO (rHuEPO), commonly used to treat anemia in CKD patients, could be a neuroprotective agent. In this systematic review, we aimed to assess the published studies investigating the cognitive benefits of rHuEPO treatment in individuals with reduced kidney function. We comprehensively searched Pubmed, Cochrane Library, Scopus, and Web of Science databases from 1990 to 2023. After selection, 24 studies were analyzed, considering study design, sample size, participant characteristics, intervention, and main findings. The collective results of these studies in CKD patients indicated that rHuEPO enhances brain function, improves performance on neuropsychological tests, and positively affects electroencephalography measurements. These findings suggest that rHuEPO could be a promising neuroprotective agent for managing CKD-related cognitive impairment.en_US
dc.identifier.citationBarbieri, M., Chiodini, P., Di Gennaro, p., Hafez, G., Liabeuf, S., Malyszko, J., Mani, L.-Y., Raso, F. M., Pepin, M., Perico, N., Simeoni, M., Zoccali, C., Tortorella, G., Capuano, A., Remuzzi, G., Capasso, G., Paolisso, G., CONNECT Action collaborators. (2024). Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review. Pharmacological Research, 203. 10.1016/j.phrs.2024.107146en_US
dc.identifier.issn1043-6618
dc.identifier.issn1096-1186
dc.identifier.scopus2-s2.0-85188142825
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4656
dc.identifier.volume203en_US
dc.identifier.wosWOS:001226735200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorHafez, Gaye
dc.language.isoen
dc.relation.ispartofPharmacological Research
dc.relation.isversionof10.1016/j.phrs.2024.107146en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCKDen_US
dc.subjectCognitionen_US
dc.subjectDarbepoetinen_US
dc.subjectErythropoietinen_US
dc.subjectHypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors (PHIs)en_US
dc.subjectNeuroprotectionen_US
dc.subjectSystematic reviewen_US
dc.subjectrHuEPOen_US
dc.titleEfficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review
dc.typeArticle

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