An updated analysis of variations in SARS-CoV-2 genome

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dc.contributor.authorUğurel, Osman Mutluhan
dc.contributor.authorAta, Oğuz
dc.contributor.authorTurgut-Balık, Dilek
dc.date.accessioned2021-05-15T11:34:01Z
dc.date.available2021-05-15T11:34:01Z
dc.date.issued2020
dc.departmentMühendislik ve Doğa Bilimleri Fakültesi, Temel Bilimler Bölümüen_US
dc.descriptionAta, Oguz/0000-0003-4511-7694
dc.description.abstractA novel pathogen, named SARS-CoV-2, has caused an unprecedented worldwide pandemic in the first half of 2020. As the SARS-CoV-2 genome sequences have become available, one of the important focus of scientists has become tracking variations in the viral genome. In this study, 30366 SARS-CoV-2 isolate genomes were aligned using the software developed by our group (ODOTool) and 11 variations in SARS-CoV-2 genome over 10% of whole isolates were discussed. Results indicated that, frequency rates of these 11 variations change between 3.56%-88.44 % and these rates differ greatly depending on the continents they have been reported. Despite some variations being in low frequency rate in some continents, C14408T and A23403G variations on Nsp12 and S protein, respectively, observed to be the most prominent variations all over the world, in general, and both cause missense mutations. It is also notable that most of isolates carry C14408T and A23403 variations simultaneously and also nearly all isolates carrying the G25563T variation on ORF3a, also carry C14408T and A23403 variations, although their location distributions are not similar. All these data should be considered towards development of vaccine and antiviral treatment strategies as well as tracing diversity of virus in all over the world.en_US
dc.identifier.doi10.3906/biy-2005-111
dc.identifier.endpage167en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue3en_US
dc.identifier.pmid32595352
dc.identifier.scopus2-s2.0-85086887022
dc.identifier.scopusqualityQ1
dc.identifier.startpage157en_US
dc.identifier.trdizinid531574
dc.identifier.urihttps://doi.org/10.3906/biy-2005-111
dc.identifier.urihttps://hdl.handle.net/20.500.12939/267
dc.identifier.volume44en_US
dc.identifier.wosWOS:000541522100005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorAta, Oğuz
dc.institutionauthorUğurel, Osman Mutluhan
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSARS-CoV-2en_US
dc.subjectCOVID-19en_US
dc.subjectGenomic Diversityen_US
dc.subjectCodon Biasen_US
dc.subjectMultiple Sequence Alignmenten_US
dc.titleAn updated analysis of variations in SARS-CoV-2 genome
dc.typeArticle

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