One step synthesis of tryptophan-isatin carbon nano dots and bio-applications as multifunctional nanoplatforms
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Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The development of natural molecule-derived carbon nano dots (CNDs) marks a significant advancement in biocompatible and sustainable nanomaterials. Tryptophan, capable of crossing the blood-brain barrier (BBB), serves as a precursor to numerous pharmacologically active compounds, while isatin and its derivatives have demonstrated anti-tumor effects, including against brain cancers. This study aimed to synthesize fluorescent CNDs from tryptophan-isatin hybrid precursor and explore their applications in glioblastoma treatment. These CNDs were characterized using techniques such as TEM, SEM-EDS, FTIR, XPS, Raman spectroscopy and UV-Vis spectrophotometry. In vitro tests using the U-87 glioblastoma cell line evaluated cell viability, affinity, and BBB permeability. The CNDs, between 4 and 7 nm in size, exhibited blue and green fluorescence, with no cytotoxic effects observed at concentrations up to 25 µg/mL. The highest BBB permeability rate was determined as 4.3 × 10⁻⁵ cm/s. Additionally, the CNDs demonstrated radiotherapeutic properties, leading to a 51 % reduction in cell viability. This research contributes to nanomedicine by introducing a novel biocompatible material with potential for targeted brain cancer imaging and therapy, while also suggesting broader applications beyond glioblastoma.
Açıklama
Anahtar Kelimeler
BBB Permeability, Carbon Nano Dots (CNDs), Cell Imaging, Multifunctional nanomaterials, Nanomedicine, Theranostic nanoplatforms, Tryptophan-isatin hybrid precursor
Kaynak
Colloids and Surfaces B-Biointerfaces
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
249
Sayı
Künye
Tok, K., Barlas, F. B., Bayır, E., Şenışık, A. M., Zihnioğlu, F., Timur, S. (2025). One step synthesis of tryptophan-isatin carbon nano dots and bio-applications as multifunctional nanoplatforms. Colloids and surfaces. B Biointerfaces, 249. 10.1016/j.colsurfb.2025.114533
