One step synthesis of tryptophan-isatin carbon nano dots and bio-applications as multifunctional nanoplatforms

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dc.contributor.authorTok, Kerem
dc.contributor.authorBarlas, F. Barış
dc.contributor.authorBayır, Ece
dc.contributor.authorŞenışık, Ahmet Murat
dc.contributor.authorZihnioğlu, Figen
dc.contributor.authorTimur, Suna
dc.date.accessioned2025-01-29T12:26:58Z
dc.date.available2025-01-29T12:26:58Z
dc.date.issued2025en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Radyoterapi Programıen_US
dc.description.abstractThe development of natural molecule-derived carbon nano dots (CNDs) marks a significant advancement in biocompatible and sustainable nanomaterials. Tryptophan, capable of crossing the blood-brain barrier (BBB), serves as a precursor to numerous pharmacologically active compounds, while isatin and its derivatives have demonstrated anti-tumor effects, including against brain cancers. This study aimed to synthesize fluorescent CNDs from tryptophan-isatin hybrid precursor and explore their applications in glioblastoma treatment. These CNDs were characterized using techniques such as TEM, SEM-EDS, FTIR, XPS, Raman spectroscopy and UV-Vis spectrophotometry. In vitro tests using the U-87 glioblastoma cell line evaluated cell viability, affinity, and BBB permeability. The CNDs, between 4 and 7 nm in size, exhibited blue and green fluorescence, with no cytotoxic effects observed at concentrations up to 25 µg/mL. The highest BBB permeability rate was determined as 4.3 × 10⁻⁵ cm/s. Additionally, the CNDs demonstrated radiotherapeutic properties, leading to a 51 % reduction in cell viability. This research contributes to nanomedicine by introducing a novel biocompatible material with potential for targeted brain cancer imaging and therapy, while also suggesting broader applications beyond glioblastoma.en_US
dc.identifier.citationTok, K., Barlas, F. B., Bayır, E., Şenışık, A. M., Zihnioğlu, F., Timur, S. (2025). One step synthesis of tryptophan-isatin carbon nano dots and bio-applications as multifunctional nanoplatforms. Colloids and surfaces. B Biointerfaces, 249. 10.1016/j.colsurfb.2025.114533en_US
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.pmid39855082
dc.identifier.scopus2-s2.0-85215594843
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5159
dc.identifier.volume249en_US
dc.identifier.wosWOS:001408393700001
dc.identifier.wosQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞenışık, Ahmet Murat
dc.language.isoen
dc.relation.ispartofColloids and Surfaces B-Biointerfaces
dc.relation.isversionof10.1016/j.colsurfb.2025.114533en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBBB Permeabilityen_US
dc.subjectCarbon Nano Dots (CNDs)en_US
dc.subjectCell Imagingen_US
dc.subjectMultifunctional nanomaterialsen_US
dc.subjectNanomedicineen_US
dc.subjectTheranostic nanoplatformsen_US
dc.subjectTryptophan-isatin hybrid precursoren_US
dc.titleOne step synthesis of tryptophan-isatin carbon nano dots and bio-applications as multifunctional nanoplatforms
dc.typeArticle

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