Restrictive effects of thalassemia on respiratory functions: One center experience

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dc.contributor.authorZengin Ersoy, Gizem
dc.contributor.authorNain, Ercan
dc.contributor.authorErtekin, Mehtap
dc.contributor.authorTerzi, Özlem
dc.contributor.authorŞaşıhüseyinoğlu, Ayşe Şenay
dc.contributor.authorDikme, Gürcan
dc.date.accessioned2023-10-18T13:00:13Z
dc.date.available2023-10-18T13:00:13Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective: Respiratory functions in thalassemia major (TM) patients concerning poor chelation are a frequently researched issue. Our study aims to evaluate the lung functions of our patients with TM in the chronic transfusion program and to correlate them with their age, ferritin levels, and pre-transfusion hemoglobin values. Methods: Height, weight, pulmonary function test (PFT) results, pre-transfusion hemoglobin levels, and ferritin levels of 97 patients (55 boys and 42 girls) without any underlying cardiac or chronic respiratory disease were recorded. PFT is consisted of forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), the ratio of FEV1/FVC to peak expiratory flow (PEF), and forced mid-exhaled flow between 25% and 75% of mid-expiratory flow (MEF25-75). Data were analyzed with IBM SPSS V25. Results: Low FVC was observed in 58 patients (60%), and low FEV1 was observed in 26 patients (27.6%). Low PEF was observed in 62 patients (64.5%), and low MEF25-75 was observed in 8 (8.3%). PFT was affected in 75 patients (78.1%). The pattern of involvement was restrictive. Age, height, and ferritin values significantly affected the MEF25-75 (p<0.05). Age and pre-transfusion hemoglobin values had a significant effect on the FVC test (p<0.05). There was a weak negative correlation between ferritin values and MEF25-75 (r=-0.221) and a weak positive correlation between pre-transfusion hemoglobin and FVC (r=0.222). Conclusion: Age and height are the main risk factors affecting FEV1, MEF25-75, and PEF. Serum ferritin has only an effect on MEF25-75 in our study. The respiratory functions of TM patients were affected in a restrictive pattern.en_US
dc.identifier.citationErsoy, G. Z., Nain, E., Ertekin, M., Terzi, O., Sasihuseyinoglu, A. S., & Dikme, G. (2023). Restrictive effects of thalassemia on respiratory functions: One center experience. Northern Clinics of Istanbul, 10(5), 589-596.en_US
dc.identifier.endpage596en_US
dc.identifier.issn2536-4553
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85174200188
dc.identifier.scopusqualityQ4
dc.identifier.startpage589en_US
dc.identifier.trdizinid1242810
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4168
dc.identifier.volume10en_US
dc.identifier.wosWOS:001087715100008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorZengin Ersoy, Gizem
dc.language.isoen
dc.relation.ispartofNorthern clinics of Istanbul
dc.relation.isversionof10.14744/nci.2023.65768en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIron Depositionen_US
dc.subjectPulmonary Functionsen_US
dc.subjectThalassemia Majoren_US
dc.titleRestrictive effects of thalassemia on respiratory functions: One center experience
dc.typeArticle

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