Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Traumatic brain injury (TBI) is the main cause of disability and mortality in individuals under the age
of 45 years. Elucidation of the molecular and structural alterations in brain tissue due to TBI is crucial
to understand secondary and long-term efects after traumatic brain injury, and to develop and apply
the correct therapies. In the current study, the molecular efects of TBI were investigated in rat brain
at 24 h and 1 month after the injury to determine acute and chronic efects, respectively by Fourier
transform infrared imaging. This study reports the time-dependent contextual and structural efects of
TBI on hippocampal brain tissue. A mild form of TBI was induced in 11-week old male Sprague Dawley
rats by weight drop. Band area and intensity ratios, band frequency and bandwidth values of specifc
spectral bands showed that TBI causes signifcant structural and contextual global changes including
decrease in carbonyl content, unsaturated lipid content, lipid acyl chain length, membrane lipid order,
total protein content, lipid/protein ratio, besides increase in membrane fuidity with an altered protein
secondary structure and metabolic activity in hippocampus 24 h after injury. However, improvement
and/or recovery efects in these parameters were observed at one month after TBI.
Açıklama
Anahtar Kelimeler
TBI, Traumatic Brain Injury, Positron Emission Tomography, Magnetic Resonance Imaging
Kaynak
Scientific Reports
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
11
Sayı
1
Künye
Ustaoglu, S. G., Ali, M. H., Rakib, F., Blezer, E. L., Van Heijningen, C. L., Dijkhuizen, R. M., & Severcan, F. (2021). Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury. Scientific reports, 11(1), 1-13.
