Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury

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dc.authorid0000-0002-7844-6876en_US
dc.authorid0000-0002-1717-2517en_US
dc.contributor.authorGarip Ustaoğlu, Şebnem
dc.contributor.authorMohamed H. M.A, Ali
dc.contributor.authorRakib, Fazle
dc.contributor.authorBlezer, Erwin L. A.
dc.contributor.authorHeijningen, Caroline L.Van
dc.contributor.authorDijkhuizen, Rick M.
dc.contributor.authorSevercan, Feride
dc.date.accessioned2022-01-16T10:14:14Z
dc.date.available2022-01-16T10:14:14Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractTraumatic brain injury (TBI) is the main cause of disability and mortality in individuals under the age of 45 years. Elucidation of the molecular and structural alterations in brain tissue due to TBI is crucial to understand secondary and long-term efects after traumatic brain injury, and to develop and apply the correct therapies. In the current study, the molecular efects of TBI were investigated in rat brain at 24 h and 1 month after the injury to determine acute and chronic efects, respectively by Fourier transform infrared imaging. This study reports the time-dependent contextual and structural efects of TBI on hippocampal brain tissue. A mild form of TBI was induced in 11-week old male Sprague Dawley rats by weight drop. Band area and intensity ratios, band frequency and bandwidth values of specifc spectral bands showed that TBI causes signifcant structural and contextual global changes including decrease in carbonyl content, unsaturated lipid content, lipid acyl chain length, membrane lipid order, total protein content, lipid/protein ratio, besides increase in membrane fuidity with an altered protein secondary structure and metabolic activity in hippocampus 24 h after injury. However, improvement and/or recovery efects in these parameters were observed at one month after TBI.en_US
dc.identifier.citationUstaoglu, S. G., Ali, M. H., Rakib, F., Blezer, E. L., Van Heijningen, C. L., Dijkhuizen, R. M., & Severcan, F. (2021). Biomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury. Scientific reports, 11(1), 1-13.en_US
dc.identifier.endpage13en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85107900469
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2173
dc.identifier.volume11en_US
dc.identifier.wosWOS:000696753700055
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGarip Ustaoğlu, Şebnem
dc.institutionauthorSevercan, Feride
dc.language.isoen
dc.relation.ispartofScientific Reports
dc.relation.isversionof10.1038/s41598-021-92015-3en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTBIen_US
dc.subjectTraumatic Brain Injuryen_US
dc.subjectPositron Emission Tomographyen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.titleBiomolecular changes and subsequent time-dependent recovery in hippocampal tissue after experimental mild traumatic brain injury
dc.typeArticle

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