Serum 25-hydroxyvitamin D correlates with endometrial HOXA10 mRNA expression
[ X ]
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Eur Rev Med Pharmacol Sci
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Endocrine Society
classified patients with serum 25-hydroxyvitamin D [25(OH)D] levels below 20 ng/ml as deficiency, 20-30 ng/ml as insufficiency, and >30 ng/
ml as replete. This study was planned to investigate the relationship between serum vitamin
D level and homeobox 10 mRNA expression in
women with polycystic ovary syndrome (PCOS).
PATIENTS AND METHODS: Thirty women
with PCOS who failed the first IVF/ICSI attempt
and were decided to have endometrial injury
before second attempt were included in the
study. Before the endometrial injury, the serum
vitamin D levels of the women were measured,
and they were divided into three equal groups
as proposed by the Endocrine Society. Group
1 consisted of vitamin D deficient women (<20
ng/mL), Group 2 consisted of vitamin D insufficient women (20-30 ng/mL), and Group 3 consisted of vitamin D replete women (>30 ng/mL).
Women in each group were injured with a Pipelle
cannula during mid-luteal phase. Endometrial
samples collected during injury were analyzed
for HOXA10 mRNA expression by RT-PCR and
correlated with serum vitamin D level.
RESULTS: When analyzing the results according
to different vitamin D thresholds, as proposed by
the Endocrine Society, HOXA10 mRNA expression
was comparable between vitamin D deficient and
vitamin D insufficient women. The HOXA10 mRNA
expression of vitamin D replete women(Group 3)
was found to be higher than both vitamin D deficient (Group 1) and vitamin D insufficient women
(Group 2). HOXA10 mRNA expression of the women in Group 3 was 3.3-fold higher than Group 1
and 2.6-fold higher than Group 2. HOXA10 mRNA
expression was correlated to the levels of vitamin
D in the Group 3 (r=0.655, p=0.02). There was no
significant correlation between serum vitamin D
levels and endometrial HOXA10 mRNA expression
of women in both Group 1 (r=0.343, p=0.06) and
Group 2 (r=0.456, p=0.08).
CONCLUSIONS: Endometrium of women with
PCOS with sufficient serum vitamin D levels express significantly higher HOXA10 mRNA than
patients with low serum vitamin D levels.
Açıklama
Anahtar Kelimeler
PCOS, Vitamin D, HOXA, Endometrium
Kaynak
Eur Rev Med Pharmacol Sci
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
26
Sayı
10
Künye
Ersahin, S. S., & Ersahin, A. (2022). Serum 25-hydroxyvitamin D correlates with endometrial HOXA10 mRNA expression. Eur Rev Med Pharmacol Sci, 26(10), 3483-3486.
