Serum 25-hydroxyvitamin D correlates with endometrial HOXA10 mRNA expression

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dc.contributor.authorErşahin, S. S.
dc.contributor.authorErşahin, A.
dc.date.accessioned2022-06-22T06:14:16Z
dc.date.available2022-06-22T06:14:16Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü,Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractEndocrine Society classified patients with serum 25-hydroxyvitamin D [25(OH)D] levels below 20 ng/ml as deficiency, 20-30 ng/ml as insufficiency, and >30 ng/ ml as replete. This study was planned to investigate the relationship between serum vitamin D level and homeobox 10 mRNA expression in women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS: Thirty women with PCOS who failed the first IVF/ICSI attempt and were decided to have endometrial injury before second attempt were included in the study. Before the endometrial injury, the serum vitamin D levels of the women were measured, and they were divided into three equal groups as proposed by the Endocrine Society. Group 1 consisted of vitamin D deficient women (<20 ng/mL), Group 2 consisted of vitamin D insufficient women (20-30 ng/mL), and Group 3 consisted of vitamin D replete women (>30 ng/mL). Women in each group were injured with a Pipelle cannula during mid-luteal phase. Endometrial samples collected during injury were analyzed for HOXA10 mRNA expression by RT-PCR and correlated with serum vitamin D level. RESULTS: When analyzing the results according to different vitamin D thresholds, as proposed by the Endocrine Society, HOXA10 mRNA expression was comparable between vitamin D deficient and vitamin D insufficient women. The HOXA10 mRNA expression of vitamin D replete women(Group 3) was found to be higher than both vitamin D deficient (Group 1) and vitamin D insufficient women (Group 2). HOXA10 mRNA expression of the women in Group 3 was 3.3-fold higher than Group 1 and 2.6-fold higher than Group 2. HOXA10 mRNA expression was correlated to the levels of vitamin D in the Group 3 (r=0.655, p=0.02). There was no significant correlation between serum vitamin D levels and endometrial HOXA10 mRNA expression of women in both Group 1 (r=0.343, p=0.06) and Group 2 (r=0.456, p=0.08). CONCLUSIONS: Endometrium of women with PCOS with sufficient serum vitamin D levels express significantly higher HOXA10 mRNA than patients with low serum vitamin D levels.en_US
dc.identifier.citationErsahin, S. S., & Ersahin, A. (2022). Serum 25-hydroxyvitamin D correlates with endometrial HOXA10 mRNA expression. Eur Rev Med Pharmacol Sci, 26(10), 3483-3486.en_US
dc.identifier.endpage3486en_US
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85131220160
dc.identifier.scopusqualityN/A
dc.identifier.startpage3483en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2490
dc.identifier.volume26en_US
dc.identifier.wosWOS:000809239500011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErşahin, S. S.
dc.language.isoen
dc.publisherEur Rev Med Pharmacol Scien_US
dc.relation.ispartofEur Rev Med Pharmacol Sci
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPCOSen_US
dc.subjectVitamin Den_US
dc.subjectHOXAen_US
dc.subjectEndometriumen_US
dc.titleSerum 25-hydroxyvitamin D correlates with endometrial HOXA10 mRNA expression
dc.typeArticle

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