Effect of nutritional supports on malnutrition, cognition, function and biomarkers of Alzheimer’s disease: a systematic review
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Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis Ltd.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
AIM To summarize the nutritional supplementation on biochemical parameters, cognition, function, Alzheimer’s Disease (AD) biomarkers and nutritional status.
MATERIALS AND METHODS PubMed, Web of Science, Korean Journal Database, Russian Science Citation Index, SciELO Citation Index, Cochrane Library and Scopus databases were searched until 16 April 2021. 22.193 records in total were reached according to inclusion and exclusion criteria. Included Studies were evaluated through the Modified Jadad Scale and gathered under four subheadings.
RESULTS Forty-eight studies with a total of 7009 AD patients were included. Souvenaid, ONS (368 ± 69 kcal), Vegenat-med, 500 mg Resveratrol, ONS (200 mL) were effective nutritional supplements on promoting weight gain and protecting malnutrition status but showed conflicting results in Body mass index, Mid-Upper-Arm Circumference and Triceps Skin Fold Thickness. ONS and a lyophilized whole supplementation Vegenat-med intake made an increase in MNA scores. While all nutritional supplements showed controversial results in biochemical parameters but caused a decrease in Hcy levels which caused reductions in brain Aβ plaque (increase serum Aβ), p-Tau and cognitive improvement. Folic acid and vitamin D decreased serum APP, BACE1, BACE1mRNA. Resveratrol, Hericium erinaceus mycelia, vitamin D and Betaine supplements improved cognitive, functional prognosis and quality of life unlike other nutritional supplements had no effect on cognitive scales.
CONCLUSIONS Better designed trials with holistic measures are needed to investigate the effect of nutritional support on the AD biomarkers, cognitive status, biochemical parameters and functional states. Also, more beneficial results can be obtained by examining the simultaneous effects of nutritional supplements with larger sample groups.
Açıklama
Anahtar Kelimeler
Alzheimer’s Biomarkers, Alzheimer’s Disease, Malnutrition, Nutritional Support, Cognitive Impairment, Functional Tests
Kaynak
International Journal of Neuroscience
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
133
Sayı
12
Künye
Kocatürk, R. R., Temizyürek, A., Özcan, Ö. Ö., Ergüzel, T. T., Karahan, M., Konuk, M., Tarhan, N. (2022). Effect of nutritional supports on malnutrition, cognition, function and biomarkers of Alzheimer’s disease: A systematic review. International Journal of Neuroscience, 133(12), 1355-1373.
