Effect of nutritional supports on malnutrition, cognition, function and biomarkers of Alzheimer’s disease: a systematic review

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dc.contributor.authorKocatürk, Rümeysa Rabia
dc.contributor.authorTemizyürek, Arzu
dc.contributor.authorÖzcan, Öznur Özge
dc.contributor.authorErgüzel, Türker Tekin
dc.contributor.authorKarahan, Mesut
dc.contributor.authorKonuk, Muhsin
dc.contributor.authorTarhan, Nevzat
dc.date.accessioned2022-07-18T09:25:21Z
dc.date.available2022-07-18T09:25:21Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractAIM To summarize the nutritional supplementation on biochemical parameters, cognition, function, Alzheimer’s Disease (AD) biomarkers and nutritional status. MATERIALS AND METHODS PubMed, Web of Science, Korean Journal Database, Russian Science Citation Index, SciELO Citation Index, Cochrane Library and Scopus databases were searched until 16 April 2021. 22.193 records in total were reached according to inclusion and exclusion criteria. Included Studies were evaluated through the Modified Jadad Scale and gathered under four subheadings. RESULTS Forty-eight studies with a total of 7009 AD patients were included. Souvenaid, ONS (368 ± 69 kcal), Vegenat-med, 500 mg Resveratrol, ONS (200 mL) were effective nutritional supplements on promoting weight gain and protecting malnutrition status but showed conflicting results in Body mass index, Mid-Upper-Arm Circumference and Triceps Skin Fold Thickness. ONS and a lyophilized whole supplementation Vegenat-med intake made an increase in MNA scores. While all nutritional supplements showed controversial results in biochemical parameters but caused a decrease in Hcy levels which caused reductions in brain Aβ plaque (increase serum Aβ), p-Tau and cognitive improvement. Folic acid and vitamin D decreased serum APP, BACE1, BACE1mRNA. Resveratrol, Hericium erinaceus mycelia, vitamin D and Betaine supplements improved cognitive, functional prognosis and quality of life unlike other nutritional supplements had no effect on cognitive scales. CONCLUSIONS Better designed trials with holistic measures are needed to investigate the effect of nutritional support on the AD biomarkers, cognitive status, biochemical parameters and functional states. Also, more beneficial results can be obtained by examining the simultaneous effects of nutritional supplements with larger sample groups.en_US
dc.identifier.citationKocatürk, R. R., Temizyürek, A., Özcan, Ö. Ö., Ergüzel, T. T., Karahan, M., Konuk, M., Tarhan, N. (2022). Effect of nutritional supports on malnutrition, cognition, function and biomarkers of Alzheimer’s disease: A systematic review. International Journal of Neuroscience, 133(12), 1355-1373.en_US
dc.identifier.endpage1373en_US
dc.identifier.issn00207454
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85133471116
dc.identifier.scopusqualityQ2
dc.identifier.startpage1355en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2671
dc.identifier.volume133en_US
dc.identifier.wosWOS:000820689600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTemizyürek, Arzu
dc.language.isoen
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofInternational Journal of Neuroscience
dc.relation.isversionof10.1080/00207454.2022.2079506en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer’s Biomarkersen_US
dc.subjectAlzheimer’s Diseaseen_US
dc.subjectMalnutritionen_US
dc.subjectNutritional Supporten_US
dc.subjectCognitive Impairmenten_US
dc.subjectFunctional Testsen_US
dc.titleEffect of nutritional supports on malnutrition, cognition, function and biomarkers of Alzheimer’s disease: a systematic review
dc.typeArticle

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