Human ß-defensins in diagnosis of head and neck cancers
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Head and neck cancers are malignant growths with high death rates, which makes the early diagnosis of the affected patients of utmost importance. Over 90% of oral cavity cancers come from squamous cells, and the tongue, oral cavity, and salivary glands are the most common locations for oral squamous cell carcinoma lesions. Human β-defensins (hBDs), which are mainly produced by epithelial cells, are cationic peptides with a wide antimicrobial spectrum. In addition to their role in antimicrobial defense, these peptides also take part in the regulation of the immune response. Recent studies produced evidence that these small antimicrobial peptides are related to the gene and protein expression profiles of tumors. While the suppression of hBDs is a common finding in head and neck cancer studies, opposite findings were also presented. In the present narrative review, the aim will be to discuss the changes in the hBD expression profile during the onset and progression of head and neck cancers. The final aim will be to discuss the use of hBDs as diagnostic markers of head and neck cancers.
Açıklama
Anahtar Kelimeler
Antimicrobial Peptides, Cancer, Diagnosis, Human Beta-Defensins, Immune Response
Kaynak
Cells
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
12
Sayı
6
Künye
Kompuinen, J., Keskin, M., Yılmaz, D., Gürsoy, M., Gürsoy, U. K. (2023). Human β-defensins in diagnosis of head and neck cancers. Cells, 12(6), 830.
