Human ß-defensins in diagnosis of head and neck cancers

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dc.contributor.authorKompuinen, Jenna
dc.contributor.authorKeskin, Mutlu
dc.contributor.authorYılmaz, Doğukan
dc.contributor.authorGürsoy, Mervi
dc.contributor.authorGürsoy, Ulvi Kahraman
dc.date.accessioned2023-04-05T06:18:24Z
dc.date.available2023-04-05T06:18:24Z
dc.date.issued2023en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Ağız ve Diş Sağlığı Programıen_US
dc.description.abstractHead and neck cancers are malignant growths with high death rates, which makes the early diagnosis of the affected patients of utmost importance. Over 90% of oral cavity cancers come from squamous cells, and the tongue, oral cavity, and salivary glands are the most common locations for oral squamous cell carcinoma lesions. Human β-defensins (hBDs), which are mainly produced by epithelial cells, are cationic peptides with a wide antimicrobial spectrum. In addition to their role in antimicrobial defense, these peptides also take part in the regulation of the immune response. Recent studies produced evidence that these small antimicrobial peptides are related to the gene and protein expression profiles of tumors. While the suppression of hBDs is a common finding in head and neck cancer studies, opposite findings were also presented. In the present narrative review, the aim will be to discuss the changes in the hBD expression profile during the onset and progression of head and neck cancers. The final aim will be to discuss the use of hBDs as diagnostic markers of head and neck cancers.en_US
dc.identifier.citationKompuinen, J., Keskin, M., Yılmaz, D., Gürsoy, M., Gürsoy, U. K. (2023). Human β-defensins in diagnosis of head and neck cancers. Cells, 12(6), 830.en_US
dc.identifier.issn2073-4409
dc.identifier.issue6en_US
dc.identifier.pmid36980171
dc.identifier.scopus2-s2.0-85151108981
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3461
dc.identifier.volume12en_US
dc.identifier.wosWOS:000954069500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKeskin, Mutlu
dc.language.isoen
dc.relation.ispartofCells
dc.relation.isversionof10.3390/cells12060830en_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial Peptidesen_US
dc.subjectCanceren_US
dc.subjectDiagnosisen_US
dc.subjectHuman Beta-Defensinsen_US
dc.subjectImmune Responseen_US
dc.titleHuman ß-defensins in diagnosis of head and neck cancers
dc.typeReview Article

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