Oral cavity calprotectin and lactoferrin levels in relation to radiotherapy
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Lactoferrin, an iron-binding glycoprotein, and calprotectin, a calcium binding protein, are sensitive markers of inflammation and their fecal levels increase during radiotherapy of prostate cancer patients. With this background, we analyzed mouthrinse calprotectin and lactoferrin levels of head- and neck-cancer patients before, during and after radiotherapy.
Methods: Twenty cancer patients (mean age 55.85 ± 15.01, 80% male), who had been planned to undergo radiotherapy to the head and neck area, were included in this study. Mouthrinse samples were collected before radiotherapy, at the 3rd and 6th weeks of radiotherapy and 4 weeks after the radiotherapy. Mouthrinse samples were analyzed for calprotectin and lactoferrin using commercial ELISA kits.
Results: Calprotectin levels increased significantly during radiotherapy (p = 0.022). Both markers, lactoferrin (p = 0.011) and calprotectin (p = 0.006), decreased significantly after the treatment.
Conclusions: Present study results may suggest that the elevations in calprotectin and lactoferrin levels during radiotherapy reflect the increased and emerging inflammatory environment in the oral cavity, thus may increase the risk of periodontal disease initiation or progression.
Açıklama
Anahtar Kelimeler
Calprotectin, Head And Neck Cancer, Lactoferrin, Periodontitis, Radiotherapy
Kaynak
Current Issues in Molecular Biology
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
44
Sayı
10
Künye
Keskin, M., Kompuinen, J., Harmankaya, İ., Karaçetin, D., Nissilä, V., Gürsoy, M., Sorsa, T., Gürsoy, U. K. (2022). Oral cavity calprotectin and lactoferrin levels in relation to radiotherapy. Current Issues in Molecular Biology, 44(10), 4439-4446.
