Oral cavity calprotectin and lactoferrin levels in relation to radiotherapy

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dc.authorid0000-0002-1045-3930en_US
dc.contributor.authorKeskin, Mutlu
dc.contributor.authorKompuinen, Jenna
dc.contributor.authorHarmankaya, İlknur
dc.contributor.authorKaraçetin, Didem
dc.contributor.authorNissilä, Verneri
dc.contributor.authorGürsoy, Mervi
dc.contributor.authorSorsa, Timo
dc.contributor.authorGürsoy, Ulvi Kahraman
dc.date.accessioned2022-11-13T07:27:30Z
dc.date.available2022-11-13T07:27:30Z
dc.date.issued2022en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Ağız ve Diş Sağlığı Programıen_US
dc.description.abstractBackground: Lactoferrin, an iron-binding glycoprotein, and calprotectin, a calcium binding protein, are sensitive markers of inflammation and their fecal levels increase during radiotherapy of prostate cancer patients. With this background, we analyzed mouthrinse calprotectin and lactoferrin levels of head- and neck-cancer patients before, during and after radiotherapy. Methods: Twenty cancer patients (mean age 55.85 ± 15.01, 80% male), who had been planned to undergo radiotherapy to the head and neck area, were included in this study. Mouthrinse samples were collected before radiotherapy, at the 3rd and 6th weeks of radiotherapy and 4 weeks after the radiotherapy. Mouthrinse samples were analyzed for calprotectin and lactoferrin using commercial ELISA kits. Results: Calprotectin levels increased significantly during radiotherapy (p = 0.022). Both markers, lactoferrin (p = 0.011) and calprotectin (p = 0.006), decreased significantly after the treatment. Conclusions: Present study results may suggest that the elevations in calprotectin and lactoferrin levels during radiotherapy reflect the increased and emerging inflammatory environment in the oral cavity, thus may increase the risk of periodontal disease initiation or progression.en_US
dc.identifier.citationKeskin, M., Kompuinen, J., Harmankaya, İ., Karaçetin, D., Nissilä, V., Gürsoy, M., Sorsa, T., Gürsoy, U. K. (2022). Oral cavity calprotectin and lactoferrin levels in relation to radiotherapy. Current Issues in Molecular Biology, 44(10), 4439-4446.en_US
dc.identifier.endpage4446en_US
dc.identifier.isbn1467-3045
dc.identifier.issn1467-3037
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85140593090
dc.identifier.scopusqualityQ3
dc.identifier.startpage4439en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2992
dc.identifier.volume44en_US
dc.identifier.wosWOS:000872403000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKeskin, Mutlu
dc.language.isoen
dc.relation.ispartofCurrent Issues in Molecular Biology
dc.relation.isversionof10.3390/cimb44100304en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalprotectinen_US
dc.subjectHead And Neck Canceren_US
dc.subjectLactoferrinen_US
dc.subjectPeriodontitisen_US
dc.subjectRadiotherapyen_US
dc.titleOral cavity calprotectin and lactoferrin levels in relation to radiotherapy
dc.typeArticle

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