Combating chronic kidney disease-associated cachexia: A literature review of recent therapeutic approaches

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dc.authorid0000-0002-3295-404X
dc.authorid0000-0001-5957-0540
dc.authorid0000-0002-8448-1539
dc.authorid0000-0002-6851-5460
dc.authorid0000-0002-1199-6881
dc.authorid0000-0003-0179-4562
dc.contributor.authorSaadat, Yalda Rahbar
dc.contributor.authorAbbasi, Amin
dc.contributor.authorHejazian, Seyyed Sina
dc.contributor.authorHekmatshoar, Yalda
dc.contributor.authorArdalan, Mohammadreza
dc.contributor.authorFarnood, Farahnoosh
dc.contributor.authorZahed, Sepideh Zununi
dc.date.accessioned2025-06-02T06:01:30Z
dc.date.available2025-06-02T06:01:30Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractIn 2008, the Society on Sarcopenia, Cachexia, and Wasting Disorders introduced a generic definition for all types of cachexia: "a complex metabolic syndrome associated with the underlying illness characterized by a loss of muscle, with or without fat loss". It is well-known that the presence of inflammatory burden in end-stage renal disease (ESRD) patients may lead to the evolution of cachexia. Since the etiology of cachexia in chronic kidney disease (CKD) is multifactorial, thus the successful treatment must involve several concomitant measures (nutritional interventions, appetite stimulants, and anti-inflammatory pharmacologic agents) to provide integrated effective therapeutic modalities to combat causative factors and alleviate the outcomes of patients. Given the high mortality rate associated with cachexia, developing new therapeutic modalities are prerequisite for ameliorating patients with CKD worldwide. The present review aims to discuss some therapeutic strategies and provide an update on advances in nutritional approaches to counteract cachexia.
dc.identifier.citationRahbar Saadat, Y., Abbasi, A., Hejazian, S. S., Hekmatshoar, Y., Ardalan, M., Farnood, F., & Zununi Vahed, S. (2025). Combating chronic kidney disease-associated cachexia: A literature review of recent therapeutic approaches. BMC nephrology, 26(1), 133.
dc.identifier.doi10.1186/s12882-025-04057-8
dc.identifier.issn1471-2369
dc.identifier.issue1
dc.identifier.pmid40069669
dc.identifier.scopus2-s2.0-105000060877
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5761
dc.identifier.volume26
dc.identifier.wosWOS:001441766300002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.institutionauthorHekmatshoar, Yalda
dc.institutionauthorid0000-0003-4683-074X
dc.language.isoen
dc.relation.ispartofBMC Nephrology
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCachexia
dc.subjectChronic kidney disease
dc.subjectEnd-stage renal disease
dc.subjectNutrition
dc.subjectWasting
dc.titleCombating chronic kidney disease-associated cachexia: A literature review of recent therapeutic approaches
dc.typeOther

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