Acidosis, cognitive dysfunction and motor impairments in patients with kidney disease
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Oxford University Press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Metabolic acidosis, defined as a plasma or serum bicarbonate
concentration <22 mmol/L, is a frequent consequence of
chronic kidney disease (CKD) and occurs in ~10–30% of
patients with advanced stages of CKD. Likewise, in patients
with a kidney transplant, prevalence rates of metabolic acidosis
range from 20% to 50%. CKD has recently been associated with
cognitive dysfunction, including mild cognitive impairment
with memory and attention deficits, reduced executive functions and morphological damage detectable with imaging.
Also, impaired motor functions and loss of muscle strength
are often found in patients with advanced CKD, which in
part may be attributed to altered central nervous system
(CNS) functions. While the exact mechanisms of how CKD
may cause cognitive dysfunction and reduced motor functions are still debated, recent data point towards the possibility that acidosis is one modifiable contributor to cognitive
dysfunction. This review summarizes recent evidence for an
association between acidosis and cognitive dysfunction in
patients with CKD and discusses potential mechanisms
by which acidosis may impact CNS functions. The review
also identifies important open questions to be answered to
improve prevention and therapy of cognitive dysfunction in
the setting of metabolic acidosis in patients with CKD
Açıklama
Anahtar Kelimeler
Acidosis, Chronic Kidney Disease, Cognitive Dysfunction, Klotho, Motor Function
Kaynak
Nephrology Dialysis Transplantation
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
37
Sayı
2
Künye
Imenez Silva, P. H., Unwin, R., Hoorn, E. J., Ortiz, A., Trepiccione, F., Nielsen, R., ... Wagner, C. A. (2022). Acidosis, cognitive dysfunction and motor impairments in patients with kidney disease. Nephrology Dialysis Transplantation, 37(2), 4-12.
