Acidosis, cognitive dysfunction and motor impairments in patients with kidney disease

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dc.contributor.authorSilva, Pedro H. Imenez
dc.contributor.authorUnwin, Robert
dc.contributor.authorHoorn, Ewout J.
dc.contributor.authorOrtiz, Alberto
dc.contributor.authorTrepiccione, Francesco
dc.contributor.authorNielsen, Rikke
dc.contributor.authorPesic, Vesna
dc.contributor.authorHafez, Gaye
dc.contributor.authorFouque, Denis
dc.contributor.authorMassy, Ziad A.
dc.contributor.authorZeeuw, Chris I. De
dc.contributor.authorCapasso, Giovambattista
dc.contributor.authorWagner, Carsten A.
dc.date.accessioned2022-01-16T10:14:45Z
dc.date.available2022-01-16T10:14:45Z
dc.date.issued2022en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalıen_US
dc.description.abstractMetabolic acidosis, defined as a plasma or serum bicarbonate concentration <22 mmol/L, is a frequent consequence of chronic kidney disease (CKD) and occurs in ~10–30% of patients with advanced stages of CKD. Likewise, in patients with a kidney transplant, prevalence rates of metabolic acidosis range from 20% to 50%. CKD has recently been associated with cognitive dysfunction, including mild cognitive impairment with memory and attention deficits, reduced executive functions and morphological damage detectable with imaging. Also, impaired motor functions and loss of muscle strength are often found in patients with advanced CKD, which in part may be attributed to altered central nervous system (CNS) functions. While the exact mechanisms of how CKD may cause cognitive dysfunction and reduced motor functions are still debated, recent data point towards the possibility that acidosis is one modifiable contributor to cognitive dysfunction. This review summarizes recent evidence for an association between acidosis and cognitive dysfunction in patients with CKD and discusses potential mechanisms by which acidosis may impact CNS functions. The review also identifies important open questions to be answered to improve prevention and therapy of cognitive dysfunction in the setting of metabolic acidosis in patients with CKDen_US
dc.identifier.citationImenez Silva, P. H., Unwin, R., Hoorn, E. J., Ortiz, A., Trepiccione, F., Nielsen, R., ... Wagner, C. A. (2022). Acidosis, cognitive dysfunction and motor impairments in patients with kidney disease. Nephrology Dialysis Transplantation, 37(2), 4-12.en_US
dc.identifier.endpage12en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85123025417
dc.identifier.scopusqualityQ1
dc.identifier.startpage4en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2176
dc.identifier.volume37en_US
dc.identifier.wosWOS:000740945100002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford University Pressen_US
dc.relation.ispartofNephrology Dialysis Transplantation
dc.relation.isversionof10.1093/ndt/gfab216en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcidosisen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectCognitive Dysfunctionen_US
dc.subjectKlothoen_US
dc.subjectMotor Functionen_US
dc.titleAcidosis, cognitive dysfunction and motor impairments in patients with kidney disease
dc.typeArticle

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