Antioxidant activity and hemocompatibility study of quercetin loaded plga nanoparticles
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Shaheed Beheshti Univ, Sch Pharmacy
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Quercetin (QU) is an important flavonoid compound presenting lots of biological activities, but its application has been limited due to its low aqueous solubility and instability. In this study, conducted to improve these properties of the quercetin, quercetin-encapsulated PLGA nanoparticles were prepared, characterized, and evaluated for antioxidant and hemolytic activity. Nanoparticles were produced by single emulsion solvent evaporation method. Four different process parameters initial QU amount, PVA concentration, PVA volume, and initial PLGA amount were investigated to obtain the nanoparticles which have minimum particle size and maximum entrapment efficiency. Synthesized nanoparticles were evaluated for particle size, entrapment efficiency, and reaction yield. Additionally, antioxidant properties and in-vitro hemolytic activity of quercetin loaded nanoparticles with different particle size were also evaluated for the first time in the literature. The antioxidant activity results showed that nanoparticles have different antioxidant activity, depending on the amount of quercetin release from nanoparticles at different particle sizes. The hemolytic activity results show that all nanoparticles exhibited favorable compatibility to red blood cells and no significant hemolytic effect was observed.
Açıklama
Ozalp, Veli Cengiz/0000-0002-7659-5990; Yilmaz, Deniz Uzunoglu/0000-0002-0933-7983; ACAR, Tayfun/0000-0001-5006-8167; UCAK, SAMET/0000-0002-3461-2481
Anahtar Kelimeler
Quercetin, Polymeric Nanoparticle, Hemocompatibility, Antioxidant Activity, Hemolytic Activity
Kaynak
Iranian Journal of Pharmaceutical Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
19
Sayı
1
