Antioxidant activity and hemocompatibility study of quercetin loaded plga nanoparticles

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dc.contributor.authorDerman, Serap
dc.contributor.authorUzunoğlu, Deniz
dc.contributor.authorAcar, Tayfun
dc.contributor.authorArasoğlu, Tulin
dc.contributor.authorUçak, Samet
dc.contributor.authorÖzalp, V. Cengiz
dc.contributor.authorMansuroğlu, Banu
dc.date.accessioned2021-05-15T11:33:59Z
dc.date.available2021-05-15T11:33:59Z
dc.date.issued2020
dc.departmentTıp Fakültesi, Biyoloji Bölümüen_US
dc.descriptionOzalp, Veli Cengiz/0000-0002-7659-5990; Yilmaz, Deniz Uzunoglu/0000-0002-0933-7983; ACAR, Tayfun/0000-0001-5006-8167; UCAK, SAMET/0000-0002-3461-2481
dc.description.abstractQuercetin (QU) is an important flavonoid compound presenting lots of biological activities, but its application has been limited due to its low aqueous solubility and instability. In this study, conducted to improve these properties of the quercetin, quercetin-encapsulated PLGA nanoparticles were prepared, characterized, and evaluated for antioxidant and hemolytic activity. Nanoparticles were produced by single emulsion solvent evaporation method. Four different process parameters initial QU amount, PVA concentration, PVA volume, and initial PLGA amount were investigated to obtain the nanoparticles which have minimum particle size and maximum entrapment efficiency. Synthesized nanoparticles were evaluated for particle size, entrapment efficiency, and reaction yield. Additionally, antioxidant properties and in-vitro hemolytic activity of quercetin loaded nanoparticles with different particle size were also evaluated for the first time in the literature. The antioxidant activity results showed that nanoparticles have different antioxidant activity, depending on the amount of quercetin release from nanoparticles at different particle sizes. The hemolytic activity results show that all nanoparticles exhibited favorable compatibility to red blood cells and no significant hemolytic effect was observed.en_US
dc.description.sponsorshipYildiz Technical University Scienti.c Research Projects Coordination DepartmentYildiz Technical University [2014-07-04-GEP03]en_US
dc.description.sponsorshipThis research has been supported by Yildiz Technical University Scienti.c Research Projects Coordination Department, project numbers 2014-07-04-GEP03.en_US
dc.identifier.doi10.22037/ijpr.2020.1101000
dc.identifier.endpage435en_US
dc.identifier.issn1735-0328
dc.identifier.issn1726-6890
dc.identifier.issue1en_US
dc.identifier.pmid32922498
dc.identifier.scopus2-s2.0-85085291371
dc.identifier.scopusqualityQ2
dc.identifier.startpage424en_US
dc.identifier.urihttps://doi.org/10.22037/ijpr.2020.1101000
dc.identifier.urihttps://hdl.handle.net/20.500.12939/262
dc.identifier.volume19en_US
dc.identifier.wosWOS:000574835400037
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorUçak, Samet
dc.language.isoen
dc.publisherShaheed Beheshti Univ, Sch Pharmacyen_US
dc.relation.ispartofIranian Journal of Pharmaceutical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectQuercetinen_US
dc.subjectPolymeric Nanoparticleen_US
dc.subjectHemocompatibilityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectHemolytic Activityen_US
dc.titleAntioxidant activity and hemocompatibility study of quercetin loaded plga nanoparticles
dc.typeArticle

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