Diagnosis of malignant pleural mesothelioma from pleural fluid by Fourier transform-infrared spectroscopy coupled with chemometrics

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dc.contributor.authorAbbas, Sherif
dc.contributor.authorÖzek, Nihal Şimşek
dc.contributor.authorEmri, Salih
dc.contributor.authorKöksal, Deniz
dc.contributor.authorSevercan, Mete
dc.contributor.authorSevercan, Feride
dc.date.accessioned2021-05-15T12:41:35Z
dc.date.available2021-05-15T12:41:35Z
dc.date.issued2018
dc.departmentTıp Fakültesi, Göğüs Hastalıkları Anabilim Dalıen_US
dc.descriptionAbbas, Sherif/0000-0001-8631-5027; Koksal, Deniz/0000-0001-8374-3691
dc.description.abstractThis study was conducted to differentiate malignant pleural mesothelioma (MPM) from lung cancer (LC) and benign pleural effusion (BPE) from pleural fluids using the diagnostic power of Fourier transform-infrared spectroscopy with attenuated total reflectance mode coupled with chemometrics. Infrared spectra of MPM (n = 24), LC (n = 20), and BPE (n = 25) were collected, and hierarchical cluster analysis (HCA) and principal component analysis (PCA) were applied to their spectra. HCA results indicated that MPM was differentiated from LC with 100% sensitivity and 100% specificity and from BPE, with 100% sensitivity and 88% specificity, which were also confirmed by PCA score plots. PCA loading plots indicated that these separations originated mainly from lipids, proteins, and nucleic acids-related spectral bands. There was significantly higher lipid, protein, nucleic acid, and glucose contents in the MPM and LC. However, the significant changes in triglyceride and cholesterol ester content, protein and nucleic acid structure, a lower membrane fluidity, and higher membrane order were only observed in the MPM. To check the classification success of some test samples/each group, soft independent modeling of class analogies was performed and 96.2% overall classification success was obtained. This approach can provide a rapid and inexpensive methodology for the efficient differentiation of MPM from other pleural effusions. (C) 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)en_US
dc.description.sponsorshipHealth Sciences Research Group (SBAG) of the Scientific and Technological Research Council of Turkey (TUBITAK) [113S294]en_US
dc.description.sponsorshipThis work was supported by the Health Sciences Research Group (SBAG) of the Scientific and Technological Research Council of Turkey (TUBITAK) (Project No: 113S294, 2013). The authors thank Dr. Sara Banu Akkas for her help with editing.en_US
dc.identifier.doi10.1117/1.JBO.23.10.105003
dc.identifier.issn1083-3668
dc.identifier.issn1560-2281
dc.identifier.issue10en_US
dc.identifier.pmid30317725
dc.identifier.scopus2-s2.0-85054888245
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1117/1.JBO.23.10.105003
dc.identifier.urihttps://hdl.handle.net/20.500.12939/825
dc.identifier.volume23en_US
dc.identifier.wosWOS:000449335800007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorEmri, Salih
dc.language.isoen
dc.publisherSpie-Soc Photo-Optical Instrumentation Engineersen_US
dc.relation.ispartofJournal of Biomedical Optics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPleuralFluiden_US
dc.subjectMalignant Pleural Mesotheliomaen_US
dc.subjectLung Canceren_US
dc.subjectFourier Transform-Infrared Spectroscopyen_US
dc.subjectChemometricsen_US
dc.subjectBenign Pleural Effusionen_US
dc.titleDiagnosis of malignant pleural mesothelioma from pleural fluid by Fourier transform-infrared spectroscopy coupled with chemometrics
dc.typeArticle

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