Polymeric-Micelle-Based delivery systems for nucleic acids
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Nucleic acids can modulate gene expression specifically. They are increasingly being
utilized and show huge potential for the prevention or treatment of various diseases. However,
the clinical translation of nucleic acids faces many challenges due to their rapid clearance after
administration, low stability in physiological fluids and limited cellular uptake, which is associated
with an inability to reach the intracellular target site and poor efficacy. For many years, tremendous
efforts have been made to design appropriate delivery systems that enable the safe and effective
delivery of nucleic acids at the target site to achieve high therapeutic outcomes. Among the different
delivery platforms investigated, polymeric micelles have emerged as suitable delivery vehicles due
to the versatility of their structures and the possibility to tailor their composition for overcoming
extracellular and intracellular barriers, thus enhancing therapeutic efficacy. Many strategies, such as
the addition of stimuli-sensitive groups or specific ligands, can be used to facilitate the delivery of
various nucleic acids and improve targeting and accumulation at the site of action while protecting
nucleic acids from degradation and promoting their cellular uptake. Furthermore, polymeric micelles
can be used to deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously to
achieve synergistic combination treatment. This review focuses on the design approaches and current
developments in polymeric micelles for the delivery of nucleic acids. The different preparation
methods and characteristic features of polymeric micelles are covered. The current state of the art of
polymeric micelles as carriers for nucleic acids is discussed while highlighting the delivery challenges
of nucleic acids and how to overcome them and how to improve the safety and efficacy of nucleic
acids after local or systemic administration.
Açıklama
Anahtar Kelimeler
Polymeric Micelle, Micelleplex, Polyplex, Polyion Complex Micelle, Cationic Polymer, Gene Delivery, Nucleic Acid, DNA, RNA
Kaynak
Pharmaceutics
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
15
Sayı
8
Künye
Sinani, G., Durgun, M. E., Cevher, E., & Özsoy, Y. (2023). Polymeric-Micelle-Based delivery systems for nucleic acids. Pharmaceutics, 15(8), 2021.
