Polymeric-Micelle-Based delivery systems for nucleic acids

Basit Öğe Kaydı
dc.contributor.authorSinani, Genada
dc.contributor.authorDurgun, Meltem Ezgi
dc.contributor.authorCevher, Erdal
dc.contributor.authorÖzsoy, Yıldız
dc.date.accessioned2023-09-19T07:20:49Z
dc.date.available2023-09-19T07:20:49Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Teknolojisi Bilimleri Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractNucleic acids can modulate gene expression specifically. They are increasingly being utilized and show huge potential for the prevention or treatment of various diseases. However, the clinical translation of nucleic acids faces many challenges due to their rapid clearance after administration, low stability in physiological fluids and limited cellular uptake, which is associated with an inability to reach the intracellular target site and poor efficacy. For many years, tremendous efforts have been made to design appropriate delivery systems that enable the safe and effective delivery of nucleic acids at the target site to achieve high therapeutic outcomes. Among the different delivery platforms investigated, polymeric micelles have emerged as suitable delivery vehicles due to the versatility of their structures and the possibility to tailor their composition for overcoming extracellular and intracellular barriers, thus enhancing therapeutic efficacy. Many strategies, such as the addition of stimuli-sensitive groups or specific ligands, can be used to facilitate the delivery of various nucleic acids and improve targeting and accumulation at the site of action while protecting nucleic acids from degradation and promoting their cellular uptake. Furthermore, polymeric micelles can be used to deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously to achieve synergistic combination treatment. This review focuses on the design approaches and current developments in polymeric micelles for the delivery of nucleic acids. The different preparation methods and characteristic features of polymeric micelles are covered. The current state of the art of polymeric micelles as carriers for nucleic acids is discussed while highlighting the delivery challenges of nucleic acids and how to overcome them and how to improve the safety and efficacy of nucleic acids after local or systemic administration.en_US
dc.identifier.citationSinani, G., Durgun, M. E., Cevher, E., & Özsoy, Y. (2023). Polymeric-Micelle-Based delivery systems for nucleic acids. Pharmaceutics, 15(8), 2021.en_US
dc.identifier.issn1999-4923
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85168797305
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4026
dc.identifier.volume15en_US
dc.identifier.wosWOS:001057383600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSinani, Genada
dc.language.isoen
dc.relation.ispartofPharmaceutics
dc.relation.isversionof10.3390/pharmaceutics15082021en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolymeric Micelleen_US
dc.subjectMicelleplexen_US
dc.subjectPolyplexen_US
dc.subjectPolyion Complex Micelleen_US
dc.subjectCationic Polymeren_US
dc.subjectGene Deliveryen_US
dc.subjectNucleic Aciden_US
dc.subjectDNAen_US
dc.subjectRNAen_US
dc.titlePolymeric-Micelle-Based delivery systems for nucleic acids
dc.typeArticle

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