Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage
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Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Radiation and Environmental Biophysics
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Radiotherapy can be employed as a therapeutic modality alone in the early stages of cancer and is used together with other
treatments such as surgery and chemotherapy in more advanced stages. However, exposure to ionizing radiation in association with radiotherapy afects several organs in the head and neck and can give rise to early and late side efects. Exposure
to ionizing radiation used in radiotherapy is known to cause cell damage by leading to oxygen stress through the production
of free oxygen radicals (such as superoxide radicals, hydroxyl radical, hydrogen peroxide, and singlet oxygen), depending
on the total radiation dosage, the fractionation rate, radiosensitivity, and linear energy transfer. The purpose of the present
study was to determine the potential protective role of a powerful and highly selective α2-adrenoreceptor agonist with a broad
pharmacological spectrum against salivary gland damage induced by ionizing radiation exposure. Forty Sprague–Dawley
rats were divided into fve groups—control, ionizing radiation, ionizing radiation+dexmedetomidine (100 µg/kg), ionizing
radiation+dexmedetomidine (200 µg/kg), and ionizing radiation+amifostine (200 mg/kg). Following exposure to ionizing radiation, we observed necrosis, fbrosis, and vascular congestions in parotid gland epithelial cells. We also observed
increases in malondialdehyde (MDA) and cleaved Caspase-3 levels and a decrease in glutathione (GSH). In groups receiving
dexmedetomidine, we observed necrotic epithelial cells, fbrosis and vascular congestion in parotid gland tissue, a decrease
in MDA levels, and an increase in GSH. Dexmedetomidine may be a promising antioxidant agent for the prevention of oxidative damage following radiation exposure.
Açıklama
Anahtar Kelimeler
Apoptosis, Dexmedetomidine, Oxidative Stress, Parotid
Kaynak
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
Sayı
Künye
Safak, G., Celiker, M., Tümkaya, L., Mercantepe, T., Rakici, S., Cinar, S., ... & Dursun, E. (2022). Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage. Radiation and Environmental Biophysics, 1-13.
