Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage

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dc.contributor.authorŞafak, Gökhan
dc.contributor.authorÇeliker, Metin
dc.contributor.authorTümkaya, Levent
dc.contributor.authorMercantepe, Tolga
dc.contributor.authorRakıcı, Sema
dc.contributor.authorÇınar, Seda
dc.contributor.authorYılmaz, Adnan
dc.contributor.authorTerzi, Suat
dc.contributor.authorDemir, Emine
dc.contributor.authorÇelebi-Erdivanlı, Özlem
dc.contributor.authorÖzergin-Coşkun, Zerrin
dc.contributor.authorKarakaş, Sibel
dc.contributor.authorBirinci, Mehmet
dc.contributor.authorDursun, Engin
dc.date.accessioned2022-04-06T08:04:37Z
dc.date.available2022-04-06T08:04:37Z
dc.date.issued2022en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü,Kulak, Burun ve Boğaz Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractRadiotherapy can be employed as a therapeutic modality alone in the early stages of cancer and is used together with other treatments such as surgery and chemotherapy in more advanced stages. However, exposure to ionizing radiation in association with radiotherapy afects several organs in the head and neck and can give rise to early and late side efects. Exposure to ionizing radiation used in radiotherapy is known to cause cell damage by leading to oxygen stress through the production of free oxygen radicals (such as superoxide radicals, hydroxyl radical, hydrogen peroxide, and singlet oxygen), depending on the total radiation dosage, the fractionation rate, radiosensitivity, and linear energy transfer. The purpose of the present study was to determine the potential protective role of a powerful and highly selective α2-adrenoreceptor agonist with a broad pharmacological spectrum against salivary gland damage induced by ionizing radiation exposure. Forty Sprague–Dawley rats were divided into fve groups—control, ionizing radiation, ionizing radiation+dexmedetomidine (100 µg/kg), ionizing radiation+dexmedetomidine (200 µg/kg), and ionizing radiation+amifostine (200 mg/kg). Following exposure to ionizing radiation, we observed necrosis, fbrosis, and vascular congestions in parotid gland epithelial cells. We also observed increases in malondialdehyde (MDA) and cleaved Caspase-3 levels and a decrease in glutathione (GSH). In groups receiving dexmedetomidine, we observed necrotic epithelial cells, fbrosis and vascular congestion in parotid gland tissue, a decrease in MDA levels, and an increase in GSH. Dexmedetomidine may be a promising antioxidant agent for the prevention of oxidative damage following radiation exposure.en_US
dc.identifier.citationSafak, G., Celiker, M., Tümkaya, L., Mercantepe, T., Rakici, S., Cinar, S., ... & Dursun, E. (2022). Comparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage. Radiation and Environmental Biophysics, 1-13.en_US
dc.identifier.endpage13en_US
dc.identifier.scopus2-s2.0-85124766850
dc.identifier.scopusqualityN/A
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2316
dc.identifier.wosWOS:000754162600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemir, Emine
dc.language.isoen
dc.publisherRadiation and Environmental Biophysicsen_US
dc.relation.isversionof10.1007/s00411-022-00964-8en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectDexmedetomidineen_US
dc.subjectOxidative Stressen_US
dc.subjectParotiden_US
dc.titleComparison of effects of dexmedetomidine and amifostine against X-ray radiation-induced parotid damage
dc.typeArticle

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