CoronaVac (Sinovac) COVID-19 vaccine-induced molecular changes in healthy human serum by infrared spectroscopy coupled with chemometrics
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TÜBİTAK
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
From the beginning of the COVID-19 coronavirus pandemic in December of 2019, the disease has infected millions of people
worldwide and caused hundreds of thousands of deaths. Since then, several vaccines have been developed. One of those vaccines is
inactivated CoronaVac-Sinovac COVID-19 vaccine. In this proof of concept study, we first aimed to determine CoronaVac-induced
biomolecular changes in healthy human serum using infrared spectroscopy. Our second aim was to see whether the vaccinated group
can be separated or not from the non-vaccinated group by applying chemometric techniques to spectral data. The results revealed
that the vaccine administration induced significant changes in some functional groups belonging to lipids, proteins and nucleic acids.
In addition, the non-vaccinated and vaccinated groups were successfully separated from each other by principal component analysis
(PCA) and linear discriminant analysis (LDA). This proof-of-concept study will encourage future studies on CoronaVac as well as other
vaccines and will lead to make a comparison between different vaccines to establish a better understanding of the vaccination outcomes
on serum biomolecules.
Açıklama
Anahtar Kelimeler
CoronaVac-Sinovac, Vaccine, COVID-19, Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR), Fourier Transform Infrared (FTIR) Spectroscopy, Multivariate Analysis
Kaynak
Turkish Journal of Biology
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
45
Sayı
4
Künye
Dogan, A., Gurbanov, R., Severcan, M., & Severcan, F. (2021). CoronaVac (Sinovac) COVID-19 vaccine-induced molecular changes in healthy human serum by infrared spectroscopy coupled with chemometrics. Turkish Journal of Biology, 45(4), 549.
