CoronaVac (Sinovac) COVID-19 vaccine-induced molecular changes in healthy human serum by infrared spectroscopy coupled with chemometrics

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dc.authorid0000-0002-6020-8327en_US
dc.authorid0000-0002-3234-3943en_US
dc.authorid0000-0002-1717-2517en_US
dc.contributor.authorDoğan, Ayça
dc.contributor.authorGurbaov, Rafig
dc.contributor.authorSevercan, Mete
dc.contributor.authorSevercan, Feride
dc.date.accessioned2022-01-16T10:15:02Z
dc.date.available2022-01-16T10:15:02Z
dc.date.issued2021en_US
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Temel Bilimler Bölümüen_US
dc.description.abstractFrom the beginning of the COVID-19 coronavirus pandemic in December of 2019, the disease has infected millions of people worldwide and caused hundreds of thousands of deaths. Since then, several vaccines have been developed. One of those vaccines is inactivated CoronaVac-Sinovac COVID-19 vaccine. In this proof of concept study, we first aimed to determine CoronaVac-induced biomolecular changes in healthy human serum using infrared spectroscopy. Our second aim was to see whether the vaccinated group can be separated or not from the non-vaccinated group by applying chemometric techniques to spectral data. The results revealed that the vaccine administration induced significant changes in some functional groups belonging to lipids, proteins and nucleic acids. In addition, the non-vaccinated and vaccinated groups were successfully separated from each other by principal component analysis (PCA) and linear discriminant analysis (LDA). This proof-of-concept study will encourage future studies on CoronaVac as well as other vaccines and will lead to make a comparison between different vaccines to establish a better understanding of the vaccination outcomes on serum biomolecules.en_US
dc.identifier.citationDogan, A., Gurbanov, R., Severcan, M., & Severcan, F. (2021). CoronaVac (Sinovac) COVID-19 vaccine-induced molecular changes in healthy human serum by infrared spectroscopy coupled with chemometrics. Turkish Journal of Biology, 45(4), 549.en_US
dc.identifier.endpage558en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85114237804
dc.identifier.scopusqualityQ1
dc.identifier.startpage549en_US
dc.identifier.trdizinid521590
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2178
dc.identifier.volume45en_US
dc.identifier.wosWOS:000691376800015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorDoğan, Ayça
dc.institutionauthorSevercan, Mete
dc.institutionauthorSevercan, Feride
dc.language.isoen
dc.publisherTÜBİTAKen_US
dc.relation.ispartofTurkish Journal of Biology
dc.relation.isversionof10.3906/biy-2105-65en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronaVac-Sinovacen_US
dc.subjectVaccineen_US
dc.subjectCOVID-19en_US
dc.subjectAttenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR)en_US
dc.subjectFourier Transform Infrared (FTIR) Spectroscopyen_US
dc.subjectMultivariate Analysisen_US
dc.titleCoronaVac (Sinovac) COVID-19 vaccine-induced molecular changes in healthy human serum by infrared spectroscopy coupled with chemometrics
dc.typeArticle

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