Genomic chronicle of SARS-CoV-2: A mutational analysis with over 1 million genome sequences
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TÜBİTAK
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Use of information technologies to analyse big data on SARS-CoV-2 genome provides an insight for tracking variations and
examining the evolution of the virus. Nevertheless, storing, processing, alignment and analyses of these numerous genomes are still a
challenge. In this study, over 1 million SARS-CoV-2 genomes have been analysed to show distribution and relationship of variations
that could enlighten development and evolution of the virus. In all genomes analysed in this study, a total of over 215M SNVs have been
detected and average number of SNV per isolate was found to be 21.83. Single nucleotide variant (SNV) average is observed to reach
31.25 just in March 2021. The average variation number of isolates is increasing and compromising with total case numbers around the
world. Remarkably, cytosine deamination, which is one of the most important biochemical processes in the evolutionary development
of coronaviruses, accounts for 46% of all SNVs seen in SARS-CoV-2 genomes within 16 months. This study is one of the most comprehensive SARS-CoV-2 genomic analysis study in terms of number of genomes analysed in an academic publication so far, and reported
results could be useful in monitoring the development of SARS-CoV-2.
Açıklama
Anahtar Kelimeler
SARS-CoV-2, COVID-19, Mutation, Variation, Genomic Analysis, Single Nucleotide Variant (SNV), 1 Million Genomes
Kaynak
Turkish Journal of Biology
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
45
Sayı
4
Künye
Uğurel, O. M., Oğuz, A. T. A., & Turgut-Balik, D. (2021). Genomic chronicle of SARS-CoV-2: a mutational analysis with over 1 million genome sequences. Turkish Journal of Biology, 45(4), 425.
