Genomic chronicle of SARS-CoV-2: A mutational analysis with over 1 million genome sequences

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dc.authorid0000-0002-5365-0950en_US
dc.authorid0000-0003-2417-4104en_US
dc.contributor.authorUğurel, Osman Mutluhan
dc.contributor.authorAta, Oğuz
dc.contributor.authorTurgut Balık, Dilek
dc.date.accessioned2022-01-16T10:13:07Z
dc.date.available2022-01-16T10:13:07Z
dc.date.issued2021en_US
dc.departmentFakülteler, Mühendislik ve Doğa Bilimleri Fakültesi, Temel Bilimler Bölümüen_US
dc.description.abstractUse of information technologies to analyse big data on SARS-CoV-2 genome provides an insight for tracking variations and examining the evolution of the virus. Nevertheless, storing, processing, alignment and analyses of these numerous genomes are still a challenge. In this study, over 1 million SARS-CoV-2 genomes have been analysed to show distribution and relationship of variations that could enlighten development and evolution of the virus. In all genomes analysed in this study, a total of over 215M SNVs have been detected and average number of SNV per isolate was found to be 21.83. Single nucleotide variant (SNV) average is observed to reach 31.25 just in March 2021. The average variation number of isolates is increasing and compromising with total case numbers around the world. Remarkably, cytosine deamination, which is one of the most important biochemical processes in the evolutionary development of coronaviruses, accounts for 46% of all SNVs seen in SARS-CoV-2 genomes within 16 months. This study is one of the most comprehensive SARS-CoV-2 genomic analysis study in terms of number of genomes analysed in an academic publication so far, and reported results could be useful in monitoring the development of SARS-CoV-2.en_US
dc.identifier.citationUğurel, O. M., Oğuz, A. T. A., & Turgut-Balik, D. (2021). Genomic chronicle of SARS-CoV-2: a mutational analysis with over 1 million genome sequences. Turkish Journal of Biology, 45(4), 425.en_US
dc.identifier.endpage435en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85114161661
dc.identifier.scopusqualityQ1
dc.identifier.startpage425en_US
dc.identifier.trdizinid520452
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2167
dc.identifier.volume45en_US
dc.identifier.wosWOS:000691376800006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorUğurel, Osman Mutluhan
dc.institutionauthorTurgut Balık, Dilek
dc.language.isoen
dc.publisherTÜBİTAKen_US
dc.relation.ispartofTurkish Journal of Biology
dc.relation.isversionof10.3906/biy-2106-8en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSARS-CoV-2en_US
dc.subjectCOVID-19en_US
dc.subjectMutationen_US
dc.subjectVariationen_US
dc.subjectGenomic Analysisen_US
dc.subjectSingle Nucleotide Variant (SNV)en_US
dc.subject1 Million Genomesen_US
dc.titleGenomic chronicle of SARS-CoV-2: A mutational analysis with over 1 million genome sequences
dc.typeArticle

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